Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

A role for brain-derived neurotrophic factor in B cell development

: Schuhmann, B.; Dietrich, A.; Sel, S.; Hahn, C.; Klingenspor, M.; Lommatzsch, M.; Gudermann, T.; Braun, A.; Renz, H.; Nockher, W.A.


Journal of neuroimmunology 163 (2005), No.1-2, pp.15-23
ISSN: 0165-5728
Journal Article
Fraunhofer ITEM ()
Neutrophins; brain-derived neurotrophic factor; Hematopoesis; bone marrow stromal cell; neuroimmunology

In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75NTR and TrkBgp95, while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+]i in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow.