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A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

 
: Nollmann, FI.; Heinrich, AK.; Brachmann, AO.; Morisseau, C.; Mukherjee, K.; Casanova-Torres, AM.; Strobl, F.; Kleinhans, D.; Kinski, S.; Schultz, K.; Beeton, ML.; Kaiser, M.; Chu, YY.; Ke, LP.; Thanwisai, A.; Bozhüyük, KAJ.; Chantratita, N.; Götz, F.; Waterfield, NR.; Vilcinskas, A.; Stelzer, EHK.; Goodrich-Blair, H.; Hammock, BD.; Bode, HB.

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ChemBioChem 16 (2015), No.5, pp.766-771
ISSN: 1439-4227
ISSN: 1439-7633
European Commission EC
FP7-HEALTH; 602773; KINDRED
European Commission EC
FP7-HEALTH; 223328; GAMEXP
English
Journal Article
Fraunhofer IME ()

Abstract
Simple urea compounds (phurealipids) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

: http://publica.fraunhofer.de/documents/N-336540.html