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Pressure fields by flow-sensitive, 4D, velocity-encoded CMR in patients with aortic coarctation

: Riesenkampff, E.; Fernandes, J.F.; Meier, S.; Goubergrits, L.; Kropf, S.; Schubert, S.; Berger, F.; Hennemuth, A.; Kuehne, T.


Journal of the American College of Cardiology. Cardiovascular imaging 7 (2014), No.9, pp.920-926
ISSN: 1936-878X
ISSN: 1876-7591
Journal Article
Fraunhofer MEVIS ()

This study compared pressure fields by 4-dimensional (4D), velocity-encoded cine (VEC) cardiac magnetic resonance imaging (CMR) with pressures measured by the clinical gold standard catheterization. Thirteen patients (n = 7 male, n = 6 female) with coarctation were studied. The 4D-VEC-CMR pressure fields were computed by solving the Pressure-Poisson equation. The agreement between catheterization and CMR-based methods was determined at 5 different measurement sites along the aorta. For all sites, the correlation coefficients between measures varied between 0.86 and 0.97 (p < 0.001). The Bland-Altman test showed good agreement between peak systolic pressure gradients across the coarctation. The nonsignificant (p > 0.2) bias was +2.3 mm Hg (± 6.4 mm Hg, 2 SDs) for calibration with dynamic pressures and +1.5 mm Hg (± 4.6 mm Hg, 2 SDs) for calibration with static pressure. In a clinical setting of coarctation, pressure fields can be accurately computed from 4D-VEC-CMR–derived flows. In patients with coarctation, this noninvasive technique might evolve to an alternative to invasive catheterization.