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Miniaturized drug delivery system TUDOS with accurate metering of microliter volumes

: Richter, M.; Wackerle, M.; Kibler, S.; Biehl, M.; Koch, T.; Müller, C.; Halter, Roman; Nuffer, J.; Zeiter, O.

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AMA Fachverband für Sensorik e.V., Wunstorf:
AMA Conferences 2013. Proceedings. With SENSOR, OPTO, IRS 2. CD-ROM : Nürnberg Exhibition Centre, Germany, 14. - 16.5.2013
Wunstorf: AMA Service, 2013
ISBN: 978-3-9813484-3-9
pp.420- 425
International Conference on Sensors and Measurement Technology (SENSOR) <16, 2013, Nuremberg>
Conference Paper, Electronic Publication
Fraunhofer EMFT ()
Fraunhofer IBMT ()
Fraunhofer ITEM ()
Fraunhofer LBF ()
Fraunhofer IZM ()
microdosing; drug delivery system; micropump; flow control; tumor therapy

A miniaturized drug delivery system for accurate dosing of drugs for therapy of cancer is presented. The weight of the system is less than 8 grams. Silicon micropumps with a stroke volume of 88 nl, and blocking pressure of 6 bar, drive the system. A novel and accurate flow monitoring principle based on capacitance measurement was developed and implemented into the drug delivery system. To prevent free flow, a self blocking safety valve was adapted to the drug micropump. Moreover, further safety features like catheter blockage detection, pump failure detection, bubble detection and a bubble separator was realized. System control and driver electronics to supply the pumps with high voltage was realized on a tiny flex PCB and integrated. System tests showed, that test dosing volumes of 12 μl can be delivered reliably with accuracy better than 4 %. The system is now ready for animal trial (rat model) for a new cancer therapy approach.