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CMOS potentiostat and sensor with multilayer membrane for wide range measurements of glucose concentrations

: Mross, Stefan; Fürst, Peter; Pierrat, Sebastien; Zimmermann, Tom; Kraft, Michael


Arregui, F.J. ; Institute of Electrical and Electronics Engineers -IEEE-:
IEEE Sensors 2014. Proceedings : Valencia Conference Centre, Valencia, Spain, Tutorials: November 2, 2014, Conference: November 3-5, 2014
Piscataway, NJ: IEEE, 2014
ISBN: 978-1-4799-0161-6
ISBN: 978-1-4799-0162-3
ISBN: 978-1-4799-0160-9
Sensors Conference <13, 2014, Valencia>
Conference Paper
Fraunhofer IMS ()
glucose sensor; wide range measurement; high glucose concentrations; bioreactor monitoring; membrane; PDMS; cellulose acetate; CMOS potentiostat; enzymatic sensor; multilayer membrane

We report on an electrochemical measurement setup comprising a CMOS potentiostat and a glucose sensor with a two-layer membrane as the first steps towards the development of an integrated in-situ sensor system for bioreactors. The potentiostat has a chip size of 2.1 x 2.5 mm2 and a linear current range from -220 nA to 240 nA with a linearity of R2 = 0.9995. For wide range measurements of glucose concentrations in cell culture media, electrodes functionalized with the enzyme glucose oxidase were spin-coated with membranes made from polydimethylsiloxane (PDMS). With these membranes, glucose concentrations up to 400 mM were measured with a linear measurement range up to 100 mM. For interferent elimination, cellulose acetate membranes were employed.