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Limit of detection comparison for surface wave biosensors

: Rizzo, Riccardo; Danz, Norbert; Michelotti, Francesco; Munzert, Peter; Sinibaldi, Alberto


Berghmans, F. ; Society of Photo-Optical Instrumentation Engineers -SPIE-, Bellingham/Wash.:
Optical Sensing and Detection III : 17-17 April 2014, Brussels, Belgium
Bellingham, WA: SPIE, 2014 (Proceedings of SPIE 9141)
ISBN: 978-1-62841-089-1
Paper 91410P
Conference "Optical Sensing and Detection" <3, 2014, Brussels>
Conference Paper
Fraunhofer IOF ()
optical biosensors; surface electromagnetic waves; label-free optical sensors; optical multilayer systems; surface plasmon polariton

Bloch surface waves (BSW) propagating at the surface of truncated, one-dimensional crystals are valid candidates to improve sensors based on surface plasmon polaritons, usually referred to as surface plasmon resonance (SPR). The low losses introduced by the dielectric BSW stacks enable to achieve resonance widths much below the ones of SPR, thus proposing improved sensing results. A simplified, bi-linear model of the resonance intensity distribution is applied to estimate the effect of the resonance properties onto the measurement noise. This yields a limit of detection (LoD) that is used to optimize a BSW supporting thin film stack and to quantitatively compare SPR and BSW sensors. The results indicate that an order of magnitude reduction of the LoD is within reach when sufficient sampling of narrow BSW resonances is achieved.