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Interaction of water with different cellulose ethers: a Raman spectroscopy and environmental scanning electron microscopy study

: Fechner, P.M.; Wartewig, S.; Kiesow, A.; Heilmann, A.; Kleinbudde, P.; Neubert, R.H.H.


Journal of pharmacy and pharmacology 57 (2005), No.6, pp.689-698
ISSN: 0022-3573
ISSN: 0373-1022
Journal Article
Fraunhofer IWM ()
ESEM; Raman spectroscopy; cellulose ether; pharmaceutical supply

Different non-ionic cellulose ethers like methyl cellulose (MC), hydroxypropyl cellulose (HPC) and hydroxypropylmethyl cellulose (HPMC) were investigated. The characterization of the cellulose ethers was carried out by thermogravimetry and sorption/desorption isotherms. Differences in the properties of the cellulose ether films were described by time-dependent contact angle measurements. Changes in molecular structure of the raw materials, gels and films caused by water contact were studied using Raman spectroscopy. Differences between the substitution types and changes due to the gel or Film formation were observed. An environmental scanning electron microscopy (ESEM) technique was used to distinguish the morphological behaviour of the cellulose ether films in contact with water. Based on in-situ ELEM experiments, the swelling and drying behaviour of the various stages of cellulose ether films (film-hydrated film-dried film) were quantified by using image analysis.