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Plasma separation by centrifugation and subsequent plasma filtration: Impact on survival in a pig model of sepsis

 
: Sauer, M.; Altrichter, J.; Mencke, T.; Klöhr, S.; Thomsen, M.; Kreutzer, H.J.; Nöldge-Schomburg, G.; Mitzner, S.R.

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Therapeutic apheresis and dialysis 16 (2012), No.3, pp.205–212
ISSN: 1091-6660
ISSN: 1744-9979
ISSN: 1744-9987
ISSN: 1526-0968
English
Journal Article
Fraunhofer IZI ()

Abstract
The impact on survival of a combination of plasma separation by centrifugation and subsequent plasma filtration was tested in a bacterial sepsis model in pigs. In this animal study 19 pigs were included. Groups II and III received an intravenous lethal dose of live Staphylococcus aureus over 1 h; group I received saline (non-septic control—NC). Groups I and II were treated by an extracorporeal circuit consisting of online centrifugation and subsequent plasma filtration (group II: treated group—TG) for 4 h; group III had no specific treatment (septic control, SC). The observation time was 7 days. All animals of group I (NC) and group II (TG) survived, while all animals of group III (SC) died during the observation time. Extracorporeal therapy with online centrifugation and plasma filtration significantly improved survival in a pig model of sepsis. Further studies with this approach are encouraged.

: http://publica.fraunhofer.de/documents/N-285712.html