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Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy

 
: Sun, Na; Hartmann, Rudolf; Lecher, Justin; Stoldt, Matthias; Funke, Susanne Aileen; Gremer, Lothar; Ludwig, Hans-Henning; Demuth, Hans-Ulrich; Kleinschmidt, Martin; Willbold, Dieter

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Journal of peptide science 18 (2012), No.11, pp.691-695
ISSN: 1075-2617
ISSN: 1099-1387
English
Journal Article
Fraunhofer IZI ()
conditions. Structural studies of pE-Aβ are crucial for better understanding the structural basis of amyloid fibril formation in the brain during development of AD, especially because an increasing number of reports indicate a decisive role of pE-Aβ for the pathogenesis of AD. Alzheimer's disease; aggregation; TFE; membrane-mimicking solvent; a-helical structure

: http://publica.fraunhofer.de/documents/N-283442.html