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Associated factors with persistent airflow limitation in asthma in U-BIOPRED

 
: Wagener, A.H.; Gibeon, D.; Yang, X.; Sousa, A.R.; Corfield, J.; Shaw, D.E.; Fowler, S.; Flemming, L.J.; Riley, J.; Jeyasingham, E.; Rowe, A.; Fichtner, K.; Robberts, G.; Bakke, P.; Singer, T.; Geiser, T.; Frey, U.; Horvarth, I.; Polosa, R.; Bonnelykke, K.; Krug, Norbert; Middelveld, R.; Dahlen, S.-E.; Dahlen, B.; Hedlin, G.; Hashimoto, S.; Nordlund, B.; Musial, J.; Woodcock, A.; Murray, C.S.; Pahus, L.; Chanez, P.; Myles, D.; Compton, C.; Higenbottam, T.W.; Montuschi, P.; Vestbo, J.; Larsson, L.; Sandstrom, T.; Bisgaard, H.; Wagers, S.S.; Howarth, P.H.; Bel, E.H.; Djukanovic, R.; Chung, K.F.; Sterk, P.J.

European Respiratory Journal 42 (2013), Supplement 57, pp.662s
ISSN: 0903-1936
ISSN: 1399-3003
European Respiratory Society (Annual Congress) <23, 2013, Barcelona>
English
Journal Article, Conference Paper
Fraunhofer ITEM ()

Abstract
Rationale
Current therapeutic options fail to prevent or reverse irreversible obstruction in some patients with asthma. Careful phenotyping will allow more detailed understanding of the underlying pathophysiology, such as the accompanying inflammatory pathways. This can promote the development of targeted prophylaxis or treatment.
Aim
To examine whether fixed airways obstruction in patients with asthma is associated with markers of airway inflammation, FeNO, total IgE, and BMI.
Methods
This was a cross-sectional analysis of the U-BIOPRED cohort. Severe asthma was defined by the IMI-criteria (Bel et al. Thorax 2011). Patients with mild/moderate asthma used ICS (500mcg FP), were (partly) controlled according to GINA-criteria, and were (ex)non-smokers (5 py). Fixed airways obstruction was defined as a postbronchodilator FEV1 or FEV1/FVC < 75% predicted with a TLC>75% predicted. Wilcoxon rank sum test was used to test for associating factors.
Results
Data were available for 148 patients, of which 118 with severe asthma. Persistent airflow limitation was observed in 46% of the patients and was significantly associated with sputum eosinophils (Sp.eos.), sputum alveolar macrophages (Sp.alv.macroph.) and age (Table 1).
(TABLE SEE LINKED PDF-FILE)
Conclusion
This preliminary analysis of the U-BIOPRED cohort shows that fixed airflow limitation in asthma is associated with elevated sputum eosinophils and lower sputum alveolar macrophages, suggesting a distinguishable inflammatory profile in the airways.

: http://publica.fraunhofer.de/documents/N-277666.html