Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

The devtox project: A comprehensive source of information on developmental abnormalities

: Buschmann, Jochen; Chahoud, Ibrahim; Kellner, Rupert; Solecki, Roland

The Toxicologist 52 (2013), No.1, pp.219, Abstract PS 1027
ISSN: 0731-9193
Society of Toxicology (Annual Meeting) <52, 2013, San Antonio/Tex.>
Journal Article, Conference Paper
Fraunhofer ITEM ()

The potential of a compound to cause adverse effects in the developing embryo or fetus is an important consideration in human health risk assessment. The terms and diagnostic criteria used to describe fetal anomalies in animal experiments need to be consistent from one laboratory to another and must be harmonized between regulatory agencies.
Consequently, the DevTox Project ( has the main objectives to harmonize the nomenclature used to describe developmental anomalies in laboratory animals and to assist in the visual recognition of developmental anomalies with the aid of photographs.
The use of a harmonized and internationally accepted nomenclature is a basic requirement for the operation of DevTox. A first approach of establishing such a harmonized terminology was made in 1997 by a publication of the International Federation of Teratology Societies IFTS (Teratology 55, 249-292, 1997). This terminology has recently been updated (Reproductive Toxicology 28, 371-434, 2009). In addition, in a series of Berlin Workshops working definitions for the two classification categories "malformation" and "variation" were agreed.
The results of all these activities were used to establish the DevTox data base. The easy-to-use Web interface allows different views of the nomenclature, images and data and a quick navigation throughout the complete site. DevTox currently contains more than 2.500 images, showing examples of external, skeletal, soft tissue and maternal-fetal anomalies in rats, mice, rabbits, hamsters, primates, Guinea 220 SOT 2013 ANNUAL MEETING pigs, minipigs, dogs and birds. It provides short descriptions of each finding and in some cases synonyms and further diagnostic notes as well as a hierarchical structure for the localizations. The system is publicly accessible and allows the electronic download of the current version of the harmonized terminology.