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Time-dependent gene expression analysis of the developing superior olivary complex

: Ehmann, H.; Hartwich, H.; Salzig, C.; Hartmann, N.; Clement-Ziza, M.; Ushakov, K.; Avraham, K.B.; Bininda-Emonds, O.R.P.; Hartmann, A.K.; Lang, P.; Friauf, E.; Nothwang, H.G.


The Journal of biological chemistry 288 (2013), No.36, pp.25865-25879
ISSN: 0021-9258
ISSN: 1083-351X
Journal Article
Fraunhofer ITWM ()

Background: The superior olivary complex (SOC) is an essential center for spatial hearing.
Results: Generation of a comprehensive qualitative and quantitative catalogue of the developmental changes in the SOC-related gene repertoire.
Conclusion: Postnatal maturation of the SOC is shaped by extensive molecular changes.
Significance: This work identifies strong candidate genes for normal and impaired hearing and genetic evidence for retrocochlear functions of deafness genes.