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SEP-induced activity and its thermographic cortical representation in a murine model

: Hoffmann, K.P.; Ruff, R.; Kirsch, M.


Biomedizinische Technik 58 (2013), No.3, pp.217-223
ISSN: 0013-5585
ISSN: 1862-278X
Bundesministerium für Bildung und Forschung BMBF
Journal Article
Fraunhofer IBMT ()

This article is a methodical report on the generation of reproducible changes in brain activity in a murine model. Somatosensory evoked potentials (SEP) are used to generate synchronized cortical activity. After electrical stimulation of mice forelimbs, the potentials were recorded with a flexible thin-film polyimide electrode structure directly from the cortex. Every registration included a simultaneous recording from both hemispheres that repeated four times to reproduce and compare the results. The SEPs in the murine model were shown to generate a very stable signal. The latency of the second positive wave (P2 wave) ranged between 16 and 19 ms, and the N1-P2 amplitude ranged between 39 and 48 mu V. In addition, the temperature distribution of the cortex was acquired using infrared thermography. Surface cortical temperature changed during electrical stimulation without a clear hemispheric correlation. These initial results could be a step toward a better understanding of the different synchronized cortical activities and basic methods of evaluation of various mathematical algorithms to detect them.