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Statistical shape modeling of human cochlea: Alignment and principal component analysis

: Poznyakovskiy, A.A.; Zahnert, T.; Fischer, B.; Lasurashvili, N.; Kalaidzidis, Y.; Mürbe, D.


Novak, C.L. ; Society of Photo-Optical Instrumentation Engineers -SPIE-, Bellingham/Wash.:
Medical Imaging 2013. Computer-Aided Diagnosis. Vol.2 : 12 - 14 February 2013, Lake Buena Vista, Florida, United States
Bellingham, WA: SPIE, 2013 (Proceedings of SPIE 8670)
ISBN: 978-0-8194-9444-3
ISSN: 1605-7422
Paper 86702N
Conference "Medical Imaging - Computer-Aided Diagnosis" <2013, Lake Buena Vista/Fla.>
Conference Paper
Fraunhofer IZFP ()

The modeling of the cochlear labyrinth in living subjects is hampered by insufficient resolution of available clinical imaging methods. These methods usually provide resolutions higher than 125 µm. This is too crude to record the position of basilar membrane and, as a result, keep apart even the scala tympani from other scalae. This problem could be avoided by the means of atlas-based segmentation. The specimens can endure higher radiation loads and, conversely, provide better-resolved images. The resulting surface can be used as the seed for atlas-based segmentation. To serve this purpose, we have developed a statistical shape model (SSM) of human scala tympani based on segmentations obtained from 10 CT image stacks. After segmentation, we aligned the resulting surfaces using Procrustes alignment. This algorithm was slightly modified to accommodate single models with nodes which do not necessarily correspond to salient features and vary in number between models. We have established correspondence by mutual proximity between nodes. Rather than using the standard Euclidean norm, we have applied an alternative logarithmic norm to improve outlier treatment. The minimization was done using BFGS method. We have also split the surface nodes along an octree to reduce computation cost. Subsequently, we have performed the principal component analysis of the training set with Jacobi eigenvalue algorithm. We expect the resulting method to help acquiring not only better understanding in interindividual variations of cochlear anatomy, but also a step towards individual models for pre-operative diagnostics prior to cochlear implant insertions.