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Targeting diamond nanoparticles into folate-receptor expressing HeLa cells

 
: Lapina, V.A.; Vorobey, A.V.; Pavich, T.A.; Opitz, J.

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Journal of Applied Spectroscopy : JAS 80 (2013), No.3, pp.414-418
ISSN: 0021-9037
ISSN: 1573-8647
English
Journal Article
Fraunhofer IZFP, Institutsteil Dresden ( IKTS-MD) ()

Abstract
We have studied binding of synthesized folic acid-diamond nanoparticle conjugates to proliferatively active HeLa cells. In order to determine the binding of the complex to the cells, we used spectral luminescence methods and microscopy, which let us visualize localization of the conjugate in the cellular system in vitro. We show that the conjugate under study binds to folate-receptor expressing HeLa cells. We have established a determining role for the folate receptor in binding of the conjugate to the cells. Our studies suggest that is it possible to use the conjugate as a targeted nanoplatform for targeted delivery of diagnostic and therapeutic agents to tumor cells.

: http://publica.fraunhofer.de/documents/N-254670.html