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Desmosine-inspired cross-linkers for hyaluronan hydrogels

: Hagel, V.; Mateescu, M.; Southan, A.; Wegner, S.V.; Nuss, I.; Haraszti, T.; Kleinhans, C.; Schuh, C.; Spatz, J.P.; Kluger, P.J.; Bach, M.; Tussetschläger, S.; Tovar, G.E.M.; Laschat, S.; Boehm, H.

Fulltext ()

Scientific Reports 3 (2013), Art. 2043, 5 pp.
ISSN: 2045-2322
Journal Article, Electronic Publication
Fraunhofer IGB ()

We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones. Generally, the obtained semi-synthetic hydrogels are form-stable, can withstand repeated stress, have a large linear-elastic range, and show strain stiffening behavior typical for biopolymer networks. In addition, it is possible to introduce a positive charge to the core of the cross-linker without affecting the gelation efficiency, or consequently the network connectivity. However, the mechanical properties strongly depend on the charge of the cross-linker. The properties of the presented hydrogels can thus be tuned in a range important for engineering of soft tissues by controlling the cross-linking density and the charge of the cross-linker.