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Label-free biosensing with single-molecule force spectroscopy

: Wei, G.; Steckbeck, S.; Köppen, S.; Ciacchi, L.C.


Chemical communications 49 (2013), No.31, pp.3239-3241
ISSN: 0022-4936
ISSN: 0009-241X
ISSN: 1359-7345
Deutsche Forschungsgemeinschaft DFG
CI 144/2
Deutsche Forschungsgemeinschaft DFG
KO 3811/3
European Commission EC
FP7-NMP; 229205; ADGLASS
Journal Article
Fraunhofer IFAM ()

We demonstrate here a novel single-molecule, label-free bioanalytical system capable of sensing the presence of specific ssDNA oligomer sequences and proteins with high selectivity and sensitivity. An ssDNA concentration of 1 nM and a Lyz concentration of 0.65 nM could be detected.