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Distribution and morphology of Clara cells in common marmosets (Callithrix jacchus)

 
: Seidel, V.; Hoffmann, R.; Braun, A.; Seehase, S.; Knauf, S.; Kaup, F.-J.; Bleyer, M.

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Journal of medical primatology 42 (2013), No.2, pp.79-88
ISSN: 0047-2565
ISSN: 1600-0684
English
Journal Article
Fraunhofer ITEM ()
Clara cell protein; mixed type secretory cell; mucin; electron microscopy; goblet cell

Abstract
Background
The objective of this investigation was to define the phenotype and spatial distribution of Clara cells within the respiratory tract of common marmosets and to distinguish them from other non-ciliated cells (goblet cells, mixed type secretory cells).
Methods
Non-ciliated cells were identified immunohistochemically using antibodies against Clara cell secretory protein and mucin 5AC. Transmission electron microscopy and scanning electron microscopy were performed to characterize Clara cells ultrastructurally.
Results
Clara cells were present throughout the tracheobronchial tree, with lowest numbers in the trachea and highest numbers in bronchioles. Goblet cells and mixed type cells were scarce in the upper conducting airways and virtually absent within bronchioles. Ultrastructurally, Clara cells showed typical apical electron-dense granules and a prominent granular endoplasmatic reticulum.
Conclusions
Clara cells of common marmosets have species-specific morphological characteristics, which suggest grouping the common marmoset phenotypically between primates and rodents.

: http://publica.fraunhofer.de/documents/N-241858.html