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Automated micro-PIV measurement in lab-on-a-chip systems

: Busek, M.; Polk, C.; Albrecht, T.; Marx, U.; König, J.; Sonntag, F.

Deutsche Gesellschaft für Biomedizinische Technik -DGBMT-; Univ. Freiburg/Brsg., Institut für Mikrosystemtechnik -IMTEK-:
BMT 2012, Biomedizinische Technik. Proceedings 46. DGBMT Jahrestagung : Jena, September 16 - 19, 2012
Berlin: De Gruyter, 2012 (Biomedizinische Technik 57, 2012, Supplement 1)
Deutsche Gesellschaft für Biomedizinische Technik (DGBMT Jahrestagung) <46, 2012, Jena>
Conference Paper, Journal Article
Fraunhofer IWS ()

Flow rate and wall shear stress are important parameters for perfused cell culture systems and should be monitored. An easy and non-invasive method is the particle image velocimetry (PIV). In this work PIV was used to characterize a cell culture system with included peristaltic pump. The time-dependent flow profile was measured on several points of the chip for different pumping speeds to figure out which forces are applied to dissolved and adherent cells. The results can be used to improve the developed pump in respect to its layout, the excitation and the position within the chip.