Abstract
This paper presents a microfluidic device addressing the field of ambulant diagnostics. The basis of the device is a hybrid system combining the advantages of conventional channel-based fluidics with those of digitally controlled droplet-based fluidics. This hybrid concept uses a micro-channel based delivery partition with a disposable reaction partition predicated on electrowetting-on-dielectric. It promises to realize a low cost approach for a Point-of-Care system with easy deployability. Implementation was done by roll embossing for the microchannels and direct structuring of the electrode elements for the EWOD substrate. The latter was laminated with a PTFE-film or coated with a nanoparticle loaded lacquer for hydrophobization. A variety of reagents were handled using a two- phase containment on the EWOD substrate, overcoming the issues associated with low surface energy fluids.