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Hierarchically structured materials for bone regenerations: biomimetic morphology, micro-mechanics and properties

: Henning, S.; Imam Khasim, H. R.; Michler, G. H.; Brandt, J.


Macromolecular symposia 315 (2012), No.1, pp.84-97
ISSN: 0258-0322
ISSN: 1022-1360
Journal Article
Fraunhofer IWM ()
bone regeneration; micromechanics; nanostructured biomaterials

The contribution describes the development of a biocompatible nanocomposite material consisting of a resorbable polymeric matrix and osteoinductive nanoparticles that can be used to manufacture compact products, porous scaffolds, hybrid nanofibers, and alternating porous/compact structures. It is shown that the material has a good balance of stiffness, strength and toughness. The material supports osteoblast proliferation. Based on a modular design principle, several prototypes for hierarchical 3D constructs are proposed.