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Pollen starch granules in bronchial inflammation

 
: Badorrek, Philipp; Dick, Melanie; Emmert, Lorenz; Schaumann, Frank; Koch, Wolfgang; Hecker, Hartmut; Murdoch, Robert; Hohlfeld, Jens M.; Krug, Norbert

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Annals of allergy, asthma, & immunology 109 (2012), No.3, pp.208-214.e6
ISSN: 0003-4738
ISSN: 1081-1206
ISSN: 1534-4436
English
Journal Article
Fraunhofer ITEM ()

Abstract
BACKGROUND:
Pollen grains with a diameter of more than 10 ?m preferentially deposit in the upper airways. Their contribution to lower airway inflammation is unclear. One hypothesis is that lower airway inflammation is mainly caused by allergen containing pollen starch granules, which are released from the pollen grains and can easily enter the peripheral airways because of their smaller size.
OBJECTIVE:
To investigate the differential effect of pollen grains and pollen starch granules on nasal symptoms and lower airway inflammation.
METHODS:
In a 2-period crossover design, 30 patients with allergic rhinitis and mild intermittent asthma underwent 2 allergen challenges on consecutive days in an environmental challenge chamber with either a mixture of pollen grains plus starch granules or starch granules only. End points were the total nasal symptom score (TNSS), nasal secretion weight, nasal flow, spirometry, and exhaled nitric oxide (eNO).
RESULTS:
The presence of pollen grains had a significant and considerable effect on increase in TNSS and secretion weight and on decrease in nasal flow. Starch granules alone only had minimal effects on nasal symptoms. Challenges with starch granules significantly increased eNO. Pollen had no effect on eNO.
CONCLUSION:
Pollen grains cause nasal symptoms but do not augment lower airway inflammation, whereas starch granules trigger lower airway inflammation but hardly induce nasal symptoms.

: http://publica.fraunhofer.de/documents/N-213893.html