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Dose-response relationship of fibrous dusts in intraperitoneal studies

: Roller, M.; Pott, Friedrich; Kamino, Kenji; Althoff, G.-H.; Bellmann, Bernd

Fulltext urn:nbn:de:0011-n-2124322 (727 KByte PDF)
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Created on: 30.8.2012

Environmental Health Perspectives 105 (1997), Supplement 5, pp.1253-1256
ISSN: 0091-6765
ISSN: 1078-0475
ISSN: 1552-9924
International Meeting on the Toxicology of Natural and Man Made Mineral Fibrous and Non-Fibrous Particles <6, 1996, Lake Placis/NY>
Journal Article, Conference Paper, Electronic Publication
Fraunhofer ITEM ()
vitreous fibers; abdominal cavity; linearity; asbestos; carcinogenicity testing; mesothelioma; rat; dose-response relationship

The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies with several fibrous dusts. Based on observed tumor incidences ranging between 10 and 90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action. Analysis of the shape of the dose-response relationship, with one apparent exception, shows virtually linear or superlinear behavior, i.e., from these data, there is no indication of a decrease in carcinogenic potency of an elementary carcinogenic unit at lower doses.