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ACGT: Advancing Clinico-genomic trials on cancer-Four years of experience

: Martin, L.; Anguita, A.; Graf, N.; Tsiknakis, M.; Brochhausen, M.; Rüping, S.; Bucur, A.; Sfakianakis, S.; Sengstag, T.; Buffa, F.; Stenzhorn, H.


Moen, A. ; European Federation of Medical Informatics -EFMI-:
User centred networked health care : Proceedings of MIE 2011, Oslo
Amsterdam: IOS Press, 2011 (Studies in health technology and informatics 169)
ISBN: 1-607-50805-2
ISBN: 978-1-607-50805-2
European Federation for Medical Informatics (MIE International Conference) <23, 2011, Oslo>
Conference Paper
Fraunhofer IAIS ()

The challenges regarding seamless integration of distributed, heterogeneous and multilevel data arising in the context of contemporary, post-genomic clinical trials cannot be effectively addressed with current methodologies. An urgent need exists to access data in a uniform manner, to share information among different clinical and research centers, and to store data in secure repositories assuring the privacy of patients. Advancing Clinico-Genomic Trials (ACGT) was a European Commission funded Integrated Project that aimed at providing tools and methods to enhance the efficiency of clinical trials in the-omics era. The project, now completed after four years of work, involved the development of both a set of methodological approaches as well as tools and services and its testing in the context of real-world clinico-genomic scenarios. This paper describes the main experiences using the ACGT platform and its tools within one such scenario and highlights the very promising results obtained.