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Sprühtrocknung von BSA- und Interferon-beta beladenen Chitosan-Partikeln

Spray drying of BSA- and interferon-beta loaded chitosan particles
 
: Gruber-Traub, C.; Burger-Kentischer, A.; Gretzinger, S.; Hirth, T.; Weber, A.

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Teipel, U.:
Produktgestaltung in der Partikeltechnologie. Themenheft : Im Mai 2011 veranstalteten 5. Symposium "Produktgestaltung in der Partikeltechnologie", Pfinztal
Weinheim: Wiley-VCH, 2012 (Chemie - Ingenieur - Technik 84.2012, Nr.3)
ISSN: 0009-286X
pp.343-348
Symposium "Produktgestaltung in der Partikeltechnologie" <5, 2011, Pfinztal>
German
Conference Paper, Journal Article
Fraunhofer IGB ()

Abstract
The formulation and oral application of therapeutic petides and proteins is still a challenge due to the proteolytic gastritic degradation and the poor adsorption mechanism out of the gut lumen. A particulate chitosan-based formulation of Interferon--1b was prepared for the future oral administration using a spray drying process. The quantification of the biological activity of Interferon--1b was carried out by means of an Anti Viral Assay (AVA) and an ELISA. The activity test showed no loss of the biological activity of Interferon after the manufacturing process.

: http://publica.fraunhofer.de/documents/N-206867.html