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Feed-control development for succinic acid production with Anaerobiospirillum succiniciproducens

: Bretz, K.; Kabasci, S.


Biotechnology & bioengineering 109 (2012), No.5, pp.1187-1192
ISSN: 0006-3592
ISSN: 1097-0290
Journal Article
Fraunhofer UMSICHT Oberhausen ()

The aim of this work was the development of a feed-control for a succinic acid production fed-batch process. The performed batch trials indicated a correlation between succinic acid production and base consumption pH control. Based on the metabolism of Anaerobiospirillum succiniciproducens, a theoretical correlation between base consumption and glucose feed was established and proved in cultivation trials. With the established fed-batch process, the succinic acid yield could be increased to 0.875 (g/g glucose) in comparison to batch processes (0.60) with similar glucose concentrations. Additionally, the results indicate that the osmolarity of the medium has a significant influence on succinic acid production.