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In vitro observation of cartilage-degeneration progression by Fourier-domain OCT

: Marx, U.; Schmitt, R.; Nebelung, S.; Tingart, M.; Lüring, C.; Rath, B.


Vo-Dinh, T. ; Society of Photo-Optical Instrumentation Engineers -SPIE-, Bellingham/Wash.:
Advanced biomedical and clinical diagnostic systems X : 22 - 24 January 2012, San Francisco, California, United States; Part of SPIE Photonics West
Bellingham, WA: SPIE, 2012 (Proceedings of SPIE 8214)
ISBN: 978-0-8194-8857-2
ISSN: 1605-7422
Paper 82140X
Conference "Advanced Biomedical and Clinical Diagnostic Systems" <10, 2012, San Francisco/Calif.>
Photonics West Conference <2012, San Francisco/Calif.>
Conference Paper
Fraunhofer IPT ()

Optical Coherence Tomography (OCT) as emerging clinical diagnostic imaging technology for dermatology and other semitransparent tissues has shown high potential in monitoring and evaluating the inner structure of articular cartilages. Since novel therapies for the limitation of cartilage degeneration in early stages of osteoarthritis are available, the early minimal invasive diagnosis of cartilage degradation is clinically essential for further treatment options. With the advancing performance and thus diagnostic opportunities of 3D-OCT devices, we carried out a systematic study by monitoring arthrotic alterations of porcine osteochondral explants that are mechanically induced under traumatic impaction. As for in-vitro tomographic imaging we utilized two OCT devices, a Thorlabs FD-OCT device with 92KHz A-scan rate and 1310nm as central wavelength and a self-developed FD-OCT device at 840nm central wavelength. This allows the comparison in image contrast and optical pene tration of cartilage tissue between these two spectral bandwidths. Further we analyzed human biopsies of articular cartilages with various degrees of osteoarthritis. The 2D and 3D OCT tomograms are characterized qualitatively regarding the inner tissue structure and quantitatively regarding the tissue absorption parameters. Therefore, we are developing image processing algorithms for the automated monitoring of cartilage tissue. A scoring system for 3D-monitoring allows the characterization of the probe volume regarding the morphological structure and tissue compactness by processing the C-scan data.