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Thy-1 (CD90) regulates the extravasation of leukocytes during inflammation

: Schubert, Kathleen; Polte, Tobias; Bönisch, Ulrike; Schader, Sina; Holtappels, Rafaela; Hildebrandt, Guido; Lehmann, Jörg; Simon, Jan C.; Anderegg, Ulf; Saalbach, Anja


European Journal of Immunology 41 (2011), No.3, pp.645-656
ISSN: 0014-2980
ISSN: 1521-4141
Journal Article
Fraunhofer IZI ()
extravasation; inflammation; Thy-1

Human Thy-1 (CD90) has been shown to mediate adhesion of inflammatory cells to activated microvascular endothelial cells via interaction with Mac-1 (CD11b/CD18) in vitro. Since there are no data showing the physiological relevance of Thy-1 for the recruitment of inflammatory cells in vivo, different inflammation models were investigated in Thy-1-deficient mice and littermate controls. In thioglycollate-induced peritonitis, the number of neutrophils and monocytes was significantly diminished in Thy-1-deficient mice. During acute lung inflammation, the extravasation of eosinophils and monocytes into the lung was significantly reduced in Thy-1-deficient mice. Moreover, during chronic lung inflammation, the influx of eosinophils and monocytes was also strongly decreased. These effects were independent of Thy-1 expression on T cells, as shown by the transplantation of WT BM into the Thy-1-deficient mice. In spite of the strong Thy-1 expression on T cells in the chimeric mice , the extravasation of the inflammatory cells in these mice was significantly diminished, compared to control mice. Finally, the altered number and composition of infiltrating leukocytes in Thy-1-deficient mice modified the chemokine/cytokine and protease expression at the site of inflammation. In conclusion, Thy-1 is involved in the control of inflammatory cell recruitment and, thus, also in conditioning the inflammatory microenvironment.