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Microstructure, cytotoxicity and corrosion of powder-metallurgical iron alloys for biodegradable bone replacement materials

 
: Wegener, B.; Sievers, B.; Utzschneider, S.; Müller, P.; Jansson, V.; Rößler, S.; Nies, B.; Stephani, G.; Kieback, B.; Quadbeck, P.

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Materials Science and Engineering, B. Solid state materials for advanced technology 176 (2011), No.20, pp.1789-1796
ISSN: 0921-5107
Symposium on Biodegradable Metals <2, 2010, Maratea>
English
Conference Paper, Journal Article
Fraunhofer IFAM, Institutsteil Pulvermetallurgie und Verbundwerkstoffe Dresden ()

Abstract
Up to now biodegradable bone implants with the ability of bearing high loads for the temporary replacement of bones or as osteosynthesis material are not available. Iron and iron based alloys have been identified as appropriate materials, since they combine high strength at medium corrosion rates. Thus, the aim of the present study is the development of a degradable iron based alloy with the perspective of using them as matrix material of cellular structures with biomechanical tailored properties. A powder metallurgical approach has been used to manufacture Fe-C, Fe-0.6P, Fe-1.6P, Fe-B and Fe-Ag samples, which have been tested with respect to their microstructure, their cytotoxicity, and their degradation rate. In order to determine the cytotoxicity of the material a monolayer culture of fibroblast and a perfusion chamber system has been chosen, which was recommended by the ISO 10993-5:1999 for biological testing of medical devices. It has been found, that in particular phosphorus features beneficial properties, since density and thus the strength of the material are increased. No corrosion inhibiting effects of phosphorus on the degradation rate have been found.

: http://publica.fraunhofer.de/documents/N-188819.html