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Evolution of the long non-coding RNAs MALAT1 and MEN beta/epsilon

: Stadler, P.F.


Ferreira, C.E.:
Advances in bioinformatics and computational biology. 5th Brazilian Symposium on Bioinformatics, BSB 2010 : Rio de Janeiro, Brazil, August 31 - September 3, 2010; Proceedings
Berlin: Springer, 2010 (Lecture notes in bioinformatics 6268)
ISBN: 3-642-15059-4
ISBN: 978-3-642-15059-3
Brazilian Symposium on Bioinformatics (BSB) <5, 2010, Rio de Janeiro>
Conference Paper
Fraunhofer IZI ()
Fraunhofer IZI ()

MALAT1 is one of the best-conserved long ncRNAs in mammals and shares several characteristics, among them nuclear retention and a non-standard processing of its 3' end, with the longer, but less well conserved, adjacent MEN RNA. We show that MALAT1 is conserved among gnathostomes (with the possible exception of birds), while MEN likely originated in the mammalian stem lineage. Evolutionary conserved features of both transcripts are discussed, including RNA secondary structure motifs and short RNA processing products.