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Automated clonal selection of high-producing hybridoma colonies from methylcellulose-based, semi-solid medium using the cell separation robot CellCelector

: Zoldan, Katharina; Knauer, Jens; Lehmann, Jörg

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Nature methods (2010), Application Notes, Art.7719, 2 pp.
ISSN: 1548-7091
ISSN: 1548-7105
Journal Article, Electronic Publication
Fraunhofer IZI ()

Monoclonal antibodies are important tools in research, diagnostics and therapy. Thus it is necessary to speed up the selection of high-producing hybridoma cell lines as it is a bottleneck in process development. Using the CellCelector™ to automatically detect and harvest in situ screened hybridoma colonies from semi-solid medium provides a rapid, simple and cost-effective alternative for faster cloning and recloning of hybridoma cell lines.