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Biosensor for calcium based on a hydrogel optical waveguide with integrated sensor proteins

: Förster, T.; Strohhöfer, C.; Bock, K.; Kasak, P.; Danko, M.; Kronekova, Z.; Nedelcev, T.; Krupa, I.; Lacik, I.


IEEE Electron Devices Society:
TRANSDUCERS 2009 : International Solid-State Sensors, Actuators and Microsystems Conference; 21 - 25 June 2009, Denver
Piscataway, NJ: IEEE, 2009
ISBN: 978-1-4244-4193-8 (online)
ISBN: 978-1-4244-4190-7 (print)
International Conference on Solid-State Sensors, Actuators, and Microsystems <15, 2009, Denver>
Conference Paper
Fraunhofer IZM-M

We present a new optical biosensor concept based on hydrogel waveguides with integrated fluorescent proteins developed as a platform for implantable sensors. In this prototype the sensor detects the presence or absence of calcium through changes in fluorescence resonance energy transfer (FRET) induced by conformational changes of a FRET protein. The protein is immobilized in a synthetic hydrogel matrix with cylindrical shape, which serves simultaneously as an optical waveguide for the excitation light. The specificity of the protein determines which molecule can be detected.