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Erste chronische Ergebnisse von flexiblen Siebelektroden als Schnittstelle zu Nervenstümpfen

Initial chronic results of flexible sieve electrodes as interface to nerve stumps
: Stieglitz, T.; Poessnecker, J.; Rosahl, S.K.; Haastert, K.; Brinker, T.; Meyer, J.U.

Biomedizinische Technik 47 (2002), Suppl.1, Pt.2, pp.692-695
ISSN: 0013-5585
ISSN: 1862-278X
Journal Article
Fraunhofer IBMT ()

Since more than 20 years, nerve stumps have been interfaced with sieve-like microsystems with integrated electrodes in experimental studies. In most cases, silicone tubes have been assembled on the microsystems to adapt the nerve and deliver a guidance structure for regeneration. Flexible, polyimide-based sieve electrodes with integrated fixation aids have been implanted chronically in an animal model. They have been adapted between the transsected ends of the sciatic nerve of rats and on the proximal stump in an amputation model. First electrophysiological experiments proved the functional reinnervation. Combining embryonic motor neurons with the sieve electrode, we propose a biohybrid system that is under investigation to functionally interface the distal part of a transsected peripheral nerve.