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Contactless handling of biological nanoparticles by dielectrophoretic forces - Tools and results

: Kentsch, J.; Geggier, P.; Gradl, G.; Müller, T.; Normann, A.; Schnelle, T.; Stelzle, M.

Verein Deutscher Ingenieure e.V. -VDI-, Kompetenzfeld Nanotechnik:
Nanofair 2005 - new ideas for industry : 4th International Nanotechnolgoy Symposium, November 29 - 30, 2005, Dresden
Düsseldorf: VDI-Verlag, 2005 (VDI-Berichte 1920)
ISBN: 3-18-091920-5
International Nanotechnolgoy Symposium (Nanofair) <4, 2005, Dresden>
Conference Paper
Fraunhofer IBMT ()

Investigation of individual or small numbers of biological micron- and sub-micron-sized biological particles such as bacteria or viruses requires means for separation, accumulation, trapping and analysis. This may be achieved employing dielectrophoresis (DEP) in microfluidic systems [1-13]. Since DEP relies on polarization effects, smaller particles require higher electric field strength and accordingly smaller electrode spacing in fluidic microsystems. A newly developed microsystem contains different dielectrophoretic function blocks, which may be applied in a versatile, flexible fashion to a wide variety of tasks. A dedicated manufacturing technology yields precise bonding [14] and small electrode spacing results in extremely high field strengths and superior dielectrophoretic performance. Among the functions integrated are: separators, band-pass filters for flexible fractionation of particulate samples, funnel-structures and field-cages for particle alignment, accumu lation and trapping, pDEP structures for field-driven adsorption of particles and molecules onto electrode surfaces. The micro-systems are transparent, exhibit virtually no fluorescence and are reusable [15], [13].