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Combinatorial vector fields and the valley structure of fitness landscapes

 
: Stadler, B.M.R.; Stadler, P.F.

:

Journal of mathematical biology 61 (2010), No.6, pp.877-898
ISSN: 0303-6812
ISSN: 1432-1416
English
Journal Article
Fraunhofer IZI ()
fitness landscape; adaptive walk; barrier tree; combinatorial vector field

Abstract
Adaptive (downhill) walks are a computationally convenient way of analyzing the geometric structure of fitness landscapes. Their inherently stochastic nature has limited their mathematical analysis, however. Here we develop a framework that interprets adaptive walks as deterministic trajectories in combinatorial vector fields and in return associate these combinatorial vector fields with weights that measure their steepness across the landscape. We show that the combinatorial vector fields and their weights have a product structure that is governed by the neutrality of the landscape. This product structure makes practical computations feasible. The framework presented here also provides an alternative, and mathematically more convenient, way of defining notions of valleys, saddle points, and barriers in landscape. As an application, we propose a refined approximation for transition rates between macrostates that are associated with the valleys of the landscape.

: http://publica.fraunhofer.de/documents/N-165337.html