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  4. Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma
 
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2003
Journal Article
Title

Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma

Abstract
Bronchial asthma represents a severe chronic inflammatory disease with increasing prevalence. The pathogenesis is characterized by complex neuroimmune dysregulation. Although the immunopathogenesis of the disease has been extensively studied, the nature of neuronal dysfunction still remains poorly understood. Recent data indicate that neurotrophins contribute to airway inflammation, broncho-obstruction and airway hyperresponsiveness. Using an established murine model of allergic bronchial asthma, the contribution of the pan-neurotrophin receptor p75(NTR) was defined. This receptor is expressed both in normal and asthmatic lungs and airways. Analysis of p75(NTR-/-) mice, as well as in vivo blocking of p75(NTR), revealed that airway inflammation is to a large extent dependent upon functional receptor expression. Furthermore, neuronal hyperreactivity depends entirely on this receptor. Based on these data, a novel molecular pathway in the neuroimmune pathogenesis of bronchial asthma could be defined.
Author(s)
Kerzel, S.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Päth, G.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Nockher, W.A.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Quarcoo, D.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Raap, U.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Groneberg, D.A.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Dinh, Q.T.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Fischer, A.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Braun, A.
Renz, H.
Univ. Marburg, Institut für Klinische Chemie und Molekulare Diagnostik
Journal
American journal of respiratory cell and molecular biology  
DOI
10.1165/rcmb.4811
Language
English
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM  
Keyword(s)
  • airway hyperresponsiveness

  • fetal calf serum

  • ovalbumin

  • phosphate-buffered saline

  • substance P

  • time of break

  • tris-buffered saline

  • tyrosin kinase receptor

  • interleukin

  • immunoglobulins

  • nerve growth factor

  • tyrosine

  • interferon

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