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Low-cost in-vitro diagnostic cartridges with integrated sensor, micropumps and reagents

: Nestler, J.; Schueller, M.; Morschhauser, A.; Otto, T.; Gessner, T.; Brandenburg, A.; Michel, D.; Bier, F.F.

Gessner, T.:
Smart systems integration 2009. CD-ROM : Brussels, Belgium, 10 - 11 March 2009
Berlin: Akademische Verlagsgesellschaft Aka, 2009
ISBN: 978-3-89838-616-6
8 pp.
European Conference & Exhibition on Integration Issues of Miniaturized Systems - MEMS, MOEMS, ICs and Electronic Components <3, 2009, Brussels>
Conference Paper
Fraunhofer ENAS ()

Integrated systems for in-vitro diagnostics are of great interest especially in the point-of-care diagnostic market. Specialized approaches have already been developed and successfully marketed, but were mainly focused on basic blood parameter determination. A technology platform for self-contained, in-vitro diagnostic cartridges has been presented. The cartridges contain a functionalized biosensor, liquid reagents and electrochemical micropumps avoiding any contamination of the readout instrument. Currently, a fabrication line is set up for the whole platform to allow for fabrication in larger quantities. The cartridge concept is open to other sensing principles, such as electrochemical ones. The whole system with reader, optical biosensor and cartridge has been presented already, there mainly focusing on the biosensor, the readout concept and the performance of the diagnostic assay. In short, the cartridge is equipped with a polymeric biosensor based on the TIRF (total internal reflection fluorescence) principle.