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Influence of transfection process on single cell impedance

 
: Kurz, C.M.; Büth, H.; Thielecke, H.

:

Institute of Physics -IOP-, London:
XIV International Conference on Electrical Bioimpedance and 11th Conference on Biomedical Applications of Electrical Impedance Tomography, ICEBI & EIT 2010 : 4-8 April 2010, University of Florida, USA
Bristol: IOP Publishing, 2010 (Journal of physics. Conference series 224.2010)
ISSN: 1742-6588
Art. 012082, 5 pp.
International Conference on Electrical Bioimpedance (ICEBI) <14, 2010, Gainesville/Fla.>
Conference on Biomedical Applications of Electrical Impedance Tomography (EIT) <11, 2010, Gainesville/Fla.>
English
Conference Paper
Fraunhofer IBMT ()

Abstract
Many new therapeutic approaches are based on gene transfection of cells. Data about dynamic interaction with cell membranes can support the selection of polymers and polyplexes regarding an optimal gene delivery reagent. A microchip/-fluidic system and an impedance-based method for monitoring the effects on individual cells after application of polymeric DNA-delivery systems is developed and evaluated. It was successfully demonstrated that the effects of polymers on the cell membrane can be monitored over time by using impedance measurements.

: http://publica.fraunhofer.de/documents/N-150088.html