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Mikrofluidischer Bioreaktor

Microfluidic bioreactor for cultivating cells and testing a substance, comprises culture chambers, which have bottom part and are arranged in gas-contact or fluid-contact with one another through opening of the bottom part, and micropump
 
: Herz, M.; Hansmann, J.; Holzhauer, P.; Richter, M.

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Frontpage ()

DE 102008056037 A: 20081105
DE 102008056037 A: 20081105
C12M0001
B01L0003
G01N0033
German
Patent, Electronic Publication
Fraunhofer EMFT ()
Fraunhofer IGB ()

Abstract
(A1) Die vorliegende Erfindung betrifft einen Bioreaktor, umfassend mindestens eine Kulturkammer mit einem Bodenteil und mindestens eine mit der Kulturkammer in Gas- oder Fluidkontakt stehende Mikropumpe sowie ein Verfahren zum Kultivieren von Zellen und ein Verfahren zum Testen von Substanzen, in denen der Bioreaktor verwendet wird.

 

DE 102008056037 A1 UPAB: 20100514 NOVELTY - The microfluidic bioreactor (100) comprises two culture chambers (20), which have a bottom part (11) and are arranged in gas-contact or fluid-contact with one another through an opening (5) of the bottom part, and a micropump (40) in gas-contact or fluid-contact with the culture chamber. The culture chamber has a membrane arranged in the opening. The micropump is arranged to each of the culture chambers. The bioreactor is built in a modular-like manner. The culture chamber and the micropump are formed as a module. The micropump has a function-critical dimension of 1-800 mu m. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a method for cultivating cells; and (2) a method for testing a substance. USE - Microfluidic bioreactor for cultivating cells and for testing a substance (all claimed), where the cells are eukaryotic and prokaryotic cells, animal-specific-, plant-specific-, fungal- or bacterial cells, viruses, living- and cultivable biological systems, cell lines, cell tissue and tissues such as skin tissue. ADVANTAGE - The microfluidic bioreactor can be simply and economically structured, and permits the culture of cells or tissues under physiological conditions, and is compact.

: http://publica.fraunhofer.de/documents/N-139581.html