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Kryospeichereinrichtung

Device for cryogenic storage of biological samples, comprises sample carrying device that is set up to accommodate samples, cryogenic container, container cooling device, intermediate storage container, transport device, and sensor device
 
: Zimmermann, H.; Schön, U.; Fuhr, G.; Leuthold, D.; Belke, M.

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Frontpage ()

DE 102008057981 A: 20081119
DE 102008057981 A: 20081119
G01N0001
German
Patent, Electronic Publication
Fraunhofer IBMT ()

Abstract
(A1) Kryospeichereinrichtung und Verfahren zum Betrieb einer Kryospeichereinrichtung, insbesondere zur Kryospeicherung biologischer Proben, umfassend eine Probentraegereinrichtung, die zur Aufnahme der Proben eingerichtet ist, einen Kryobehaelter, der zur Aufnahme der Probentraegereinrichtung eingerichtet ist, eine Behaelterkuehleinrichtung, mit welcher der Kryobehaelter kuehlbar ist, ein Zwischenlagerbehaelter, der zur Zwischenlagerung der Probentraegereinrichtung eingerichtet ist, eine Transporteinrichtung, mit der die Probentraegereinrichtung zwischen dem Kryobehaelter und dem Zwischenlagerbehaelter beweglich ist, und eine Sensoreinrichtung, mit der mindestens ein Betriebsparameter der Kryospeichereinrichtung erfassbar ist. Dabei ist die Transporteinrichtung eingerichtet, in Abhaengigkeit von einem Ausgangssignal der Sensoreinrichtung bei Erfassung eines vorbestimmten Betriebszustandes der Kryospeichereinrichtung aktivierbar ist, so dass die Probentraegereinrichtung vom Kryobehaelter in den Zwischenlagerbehaelter bewegt wird. Zusaetzlich oder alternativ kann eine Zwischenlagerkuehleinrichtung, die zur Kuehlung des Zwischenlagerbehaelters eingerichtet ist, in Abhaengigkeit von einem Ausgangssignal der Sensoreinrichtung aktiviert werden.

 

WO 2010057589 A1 UPAB: 20100609 NOVELTY - The cryogenic storage device (100) comprises a sample carrying device (10) that is set up to accommodate samples, a cryogenic container (20) that is set up to accommodate the sample carrying device, a container cooling device with which the cryogenic container is cooled, an intermediate storage container (40) that is set up for intermediate storage of the sample carrying device, a transport device (50) with which the sample carrying device is moved between the cryogenic container and the intermediate storage container, and a sensor device. DETAILED DESCRIPTION - The cryogenic storage device (100) comprises a sample carrying device (10) that is set up to accommodate samples, a cryogenic container (20) that is set up to accommodate the sample carrying device, a container cooling device with which the cryogenic container is cooled, an intermediate storage container (40) that is set up for intermediate storage of the sample carrying device, a transport device (50) with which the sample carrying device is moved between the cryogenic container and the intermediate storage container, and a sensor device with which an operating parameter of the cryogenic storage device is registered. The transport device is set up to be activated in dependence on an output signal from the sensor device upon registering a predetermined operating condition of the cryogenic storage device, so that the sample carrying device is moved from the cryogenic container to the intermediate storage container. The device further includes an intermediate storage cooling device that is set up for cooling the intermediate storage container is activated in dependence on the output signal of the sensor device upon registering the predetermined operating condition of the cryogenic storage device. The sensor device has one of the sensor types, which comprise a sample carrying temperature sensor that is designed for detecting temperature in the sample carrying device, a container temperature sensor that is designed for detecting temperature in the cryogenic container, an intermediate storage temperature sensor that is designed for detecting temperature in the intermediate storage container, a coolant sensor, that is designed for detecting a coolant consumption of the cooling device, a level sensor in the cryogenic container, a flow sensor that is designed for detecting an operating condition of a coolant valve of the cooling device, a camera device that is designed for image reception in the intermediate storage container and/or the cryogenic container, a pressure sensor that is designed for detecting a low pressure in an evacuated wall of the cryogenic container, a sample carrying test sensor that is designed for detecting an operating condition of the sample carrying device, a gas sensor for detecting a gas composition in the intermediate storage container and/or the cryogenic container and/or a time measuring device for detecting a time period during which the sample carrying device is present in the intermediate storage container. The cryogenic storage device has a locking device, which is designed for introducing and/or withdrawing samples in the intermediate storage container. The intermediate storage container comprises a storage tower, which is disposed on an upper side of the cryogenic container, and an intermediate storage closure device with which an inner chamber of the storage tower is closed. The transport device comprises an elevator, which is disposed on an upper end of the storage tower, a robot arm, and/or an extendable frame. An INDEPENDENT CLAIM is included for a method for operating a cryogenic storage device. USE - Device for cryogenic storage of biological samples useful in the field of biology, biotechnology, pharmacology and medicine. ADVANTAGE - The device ensures reliable and safe cryogenic storage of the biological samples over a longer period of time without ice formation.

: http://publica.fraunhofer.de/documents/N-139566.html