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Hochauflösende Bildgebung der gastrointestinalen Wandschichten von Schweine- und Humanpräparaten mittels endoluminaler MR-Spule: Korrelation zur Histologie

High-Resolution Imaging of the Layers of the Gastrointestinal Wall of Pig and Human Specimens Using an Endoluminal MR Receiver Coil: Correlation to Histology
: Kramer, S.; Palmowski, M.; Macher-Göppinger, S.; Müller, M.; Volke, F.; Düx, M.; Kauczor, H.U.; Grenacher, L.


RöFo. Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 181 (2009), No.11, pp.1073-1080
ISSN: 0340-1618
ISSN: 0936-6652
ISSN: 1433-5972
ISSN: 1438-9029
Journal Article
Fraunhofer IBMT ()

Purpose: High-resolution MR imaging of the layers of the gastrointestinal wall to provide a foundation for tumor staging based on morphological criteria. Materials and Methods: Over a period of 12 months, miscellaneous parts of the gastrointestinal tract of 15 human specimens and 30 porcine specimens were scanned using a 1.5 Tesla clinical MRI scanner combined with an endoluminal receiver coil. The sequences used were T1-weighted opposed-phase, T2-weighted turbo spin echo with fat saturation and fast T2-weighted inversion recovery. The number of differentiable layers, their width and the signal intensity were documented. Then, the results were compared with histological specimens in order to link the imaged wall layers to the anatomical layers. Spearman's Rank Correlation was used to determine the soundness of the link between the images and their related histology. Results: For both human and animal specimens, the MRI scanning produced 3 to 5, maximum 6 (pig), differentiable layers. The mucosa, submucosa and muscularis could be differentiated with a hyperintense, hypointense and intermediary signal, respectively. The subserosal layer displayed a hypointense signal. Conclusion: High-resolution MRI is able to produce differentiable images of the anatomical layers of the gastrointestinal wall in both humans and pigs. Accordingly, it is possible to use MR imaging to diagnose the extent of local tumor infiltration of the gastrointestinal wall.