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Defining genes: A computational framework

: Stadler, P.F.; Prohaska, S.J.; Forst, C.V.; Krakauer, D.C.


Theory in Biosciences 128 (2009), No.3, pp.165-170
ISSN: 1431-7613
Journal Article
Fraunhofer IZI ()

The precise elucidation of the gene concept has become the subject of intense discussion in light of results from several, large high-throughput surveys of transcriptomes and proteomes. In previous work, we proposed an approach for constructing gene concepts that combines genomic heritability with elements of function. Here, we introduce a definition of the gene within a computational framework of cellular interactions. The definition seeks to satisfy the practical requirements imposed by annotation, capture logical aspects of regulation, and encompass the evolutionary property of homology.