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  4. Effects of NGF application on airway inflammation in a Murine model of allergic bronchial asthma
 
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2002
Conference Paper
Title

Effects of NGF application on airway inflammation in a Murine model of allergic bronchial asthma

Abstract
There is growing evidence that besides the classical Th2 cytokines IL-4, IL-5 and IL-13, the nerve growth factor (NGF), a member of the neurotrophin family, plays a central role in the development of allergic inflammation, questions concerning the function of this factor have been raised. Recent research points to a dual role of NGF, in the one hand acting on neurons as a mediator of airway hyperresponsiveness, and, on the other hand, being a proinflammatory cytokine which enhances the Th2 response. In a murine model of allergic bronchial asthma, we provide further evidence for the proinflammatory properties of NGF. NGF is produced by immune cells generating a peribrochial infiltrate during allergic inflammation.
Author(s)
Quarcoo, D.
Päth, G.
Lommatzsch, M.
Renz, H.
Braun, A.
Mainwork
Crucial issues in inhalation research - mechanistic, clinical and epidemiologic  
Conference
International Inhalation Symposium 2001  
Language
English
ITA  
Keyword(s)
  • murine model

  • Asthma

  • inflammation

  • nerve growth factor

  • mouse

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