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Effects of NGF application on airway inflammation in a Murine model of allergic bronchial asthma

: Quarcoo, D.; Päth, G.; Lommatzsch, M.; Renz, H.; Braun, A.

Heinrich, U.; Mohr, U. ; Fraunhofer-Institut für Toxikologie und Aerosolforschung -ITA-, Hannover:
Crucial issues in inhalation research - mechanistic, clinical and epidemiologic : 8th International Inhalation Symposium
Stuttgart: Fraunhofer IRB Verlag, 2002
ISBN: 3-8167-6176-3
ISBN: 978-3-8167-6176-1
International Inhalation Symposium <8, 2001, Hannover>
Conference Paper
Fraunhofer ITA ( ITEM) ()
murine model; Asthma; inflammation; nerve growth factor; mouse

There is growing evidence that besides the classical Th2 cytokines IL-4, IL-5 and IL-13, the nerve growth factor (NGF), a member of the neurotrophin family, plays a central role in the development of allergic inflammation, questions concerning the function of this factor have been raised. Recent research points to a dual role of NGF, in the one hand acting on neurons as a mediator of airway hyperresponsiveness, and, on the other hand, being a proinflammatory cytokine which enhances the Th2 response. In a murine model of allergic bronchial asthma, we provide further evidence for the proinflammatory properties of NGF. NGF is produced by immune cells generating a peribrochial infiltrate during allergic inflammation.