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Application of modified bead cellulose as a carrier of active ingredients

: Volkert, B.; Wolf, B.; Fischer, S.; Li, N.; Lou, C.


Heinze, T.:
Novel aspects of the renewable resource cellulose : Selected contributions from the conference: 50th Cellulose Symposium, in: Wiesbaden (Germany), June 24 - 26, 2008
Weinheim: Wiley-VCH, 2009 (Macromolecular symposia 280)
ISSN: 1022-1360
ISSN: 0258-0322
Cellulose Symposium <50, 2008, Wiesbaden>
Zellcheming Meeting <103, 2008, Wiesbaden>
Conference Paper, Journal Article
Fraunhofer IAP ()

A new kind of very fine disperse porous bead cellulose is modified by chemical treatments to 2,3-dialdehyde cellulose, carboxymethyl and dihydrogenphosphate cellulose. Model drugs like benzocaine and prazosin are coupled to these modified bead celluloses by covalent and ionic linkage, respectively and compressed to tablets. Compression mixtures with low loaded benzocaine conjugates release with medium rate. Linkage of prazosin cation to the anionic derivatives of bead cellulose leads to fast release of poor soluble ionic drug.