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Biomonitoring of benzene and toluene in human blood by headspace-solid-phase microextraction

 
: Schimming, E.; Levsen, K.; Köhme, C.; Schürmann, W.

:

Fresenius Journal of Analytical Chemistry 363 (1999), pp.88-91
ISSN: 0937-0633
English
Journal Article
Fraunhofer ITA ( ITEM) ()
benzene; toluene; blood

Abstract
A simple and rapid method for the determination of benzene and toluene in whole blood by headspace-solid-phase microextraction (HS-SPME) is described. Using SPME fibres coated with 65 ug carboxene/polydimethylsiloxane, limits of quantification (LOQ) of 5 ng/L for benzene and 25 ng/L for toluene are achieved. As a result of its large linear range (i. e. 5-5000 ng/L for benzene) the method is suitable for biomonitoring of both occupationally and environmentally exposed people. The reproducibility of the determination of benzene is <= 8%. An interlaboratory comparison demonstrated that the method proposed here compares favorably with existing methods (dynamic headspace, purge and trap).

: http://publica.fraunhofer.de/documents/B-63858.html