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  4. Engineering support vector machine kernels that recognize translation initiation sites
 
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2000
Journal Article
Title

Engineering support vector machine kernels that recognize translation initiation sites

Abstract
Motivation: In order to extract protein sequences from nucleotide sequences, it is an important step to recognize points at which regions start that code for proteins. These points are called translation initiation sites (TIS). Results: The task of finding TIS can be modeled as a classification problem. We demonstrate the applicability of support vector machines for this task, and show how to incorporate prior biological knowledge by engineering an appropriate kernel function. With the described techniques the recognition performance can be improved by 26% over leading existing approaches. We provide evidence that existing related methods (e.g. ESTScan) could profit from advanced TIS recognition.
Author(s)
Zien, A.
Rätsch, G.
Mika, S.
Schölkopf, B.
Lengauer, T.
Müller, K.-R.
Journal
Bioinformatics  
DOI
10.1093/bioinformatics/16.9.799
Language
English
FIRST
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
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