Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019An advanced non-animal model for cultivation and pharmacological perturbation of human tumor tissue
Böpple, K.; Dong, M.; Winkler, B.; Janssen, N.; Kleih, M.; Essmann, F.; Walles, Heike; Ott, G.; Schwab, M.; Aulitzky, W.E.
Abstract
2019Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors
Schwedhelm, Ivo; Zdzieblo, Daniela; Appelt-Menzel, Antje; Berger, Constantin; Schmitz, Tobias; Schuldt, Bernhard; Franke, Andre; Müller, Franz-Josef; Pless, Ole; Schwarz, Thomas; Wiedemann, Philipp; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2019A coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals after topical exposure
Schellenberger, Mario T.; Bock, Udo; Hennen, Jennifer; Groeber-Becker, Florian Kai; Walles, Heike; Blömeke, Brunhilde
Zeitschriftenaufsatz
2019Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model
Ingendoh-Tsakmakidis, Alexandra; Mikolai, Carina; Winkel, Andreas; Szafrański, Szymon P.; Falk, Christine S.; Rossi, Angela; Walles, Heike; Stiesch, Meike
Zeitschriftenaufsatz
2019Effects of commensal biofilms on a peri-implant mucosa in a three dimensional model
Mikolai, C.; Ingendoh-Tsakmakidis, A.; Winkel, A.; Kommerein, N.; Falk, C.S.; Rossi, Angela; Walles, Heike; Stiesch, M.
Abstract
2019EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells
Kailayangiri, Sareetha; Altvater, Bianca; Lesch, Stefanie; Balbach, Sebastian; Göttlich, Claudia; Kühnemundt, Johanna; Mikesch, Jan-Henrik; Schelhaas, Sonja; Jamitzky, Silke; Meltzer, Jutta; Farwick, Nicole; Greune, Lea; Fluegge, Maike; Kerl, Kornelius; Lode, Holger N.; Siebert, Nikolai; Müller, Ingo; Walles, Heike; Hartmann, Wolfgang; Rossig, Claudia
Zeitschriftenaufsatz
2019Generation of porous 3D-scaffolds based on electrospun nanofibers
Weigel, Tobias; Schmitz, Tobias; Jannasch, Maren; Schürlein, Sebastian; Al-Hijailan, Reem; Suliman, Salwa; Walles, Heike; Hansmann, Jan
Abstract
2019An in vitro model mimics the contact of biomaterials to blood components and the reaction of surrounding soft tissue
Jannasch, Maren; Gaetzner, Sabine; Groeber, Florian; Weigel, Tobias; Walles, Heike; Schmitz, Tobias; Hansmann, Jan
Zeitschriftenaufsatz
2019Reepithelialization in focus: Non-invasive monitoring of epidermal wound healing in vitro
Kiesewetter, Lisa; Littau, Laura; Walles, Heike; Boccaccini, Aldo R.; Groeber-Becker, Florian
Zeitschriftenaufsatz
2019Reepithelialization in Focus: Rapid Screening of Wound Closure Using Organotypic Skin Models
Kiesewetter, Lisa; Littau, Laura; Boccaccini, Aldo R.; Walles, Heike; Groeber-Becker, Florian Kai
Abstract
2019Spin echo based cardiac diffusion imaging at 7T: An ex vivo study of the porcine heart at 7T and 3T
Lohr, David; Terekhov, Maxim; Weng, Andreas Max; Schroeder, Anja; Walles, Heike; Schreiber, Laura Maria
Zeitschriftenaufsatz
2018Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet
Mühlemann, Markus; Zdzieblo, Daniela; Friedrich, Alexandra; Berger, Constantin; Otto, Christoph; Walles, Heike; Koepsell, Hermann; Metzger, Marco
Zeitschriftenaufsatz
2018A combined tissue-engineered/in silico signature tool patient stratification in lung cancer
Göttlich, Claudia; Kunz, Meik; Zapp, Cornelia; Nietzer, Sarah L.; Walles, Heike; Dandekar, Thomas; Dandekar, Gudrun
Zeitschriftenaufsatz
2018Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation
Ramani-Mohan, Ram-Kumar; Schwedhelm, Ivo; Finne-Wistrand, Anna; Krug, Melanie; Schwarz, Thomas; Jakob, Franz; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2018Evaluation of a miniaturized biologically vascularized scaffold in vitro and in vivo
Kress, Sebastian; Baur, Johannes; Otto, Christoph; Burkard, Natalie; Braspenning, Joris; Walles, Heike; Nickel, Joachim; Metzger, Marco
Zeitschriftenaufsatz
2018High-resolution and semidynamic vessel wall imaging kinetics obtained from stable radical MRI in ex-vivo porcine aorta
Pali, M.; Terekhov, M.; Wittke, C.; Wagner, N.; Schroeder, D.; Walles, Heike; Erguen, S.; Zernecke-Madsen, A.; Schreiber, L.M.
Abstract
2018An in vitro coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals
Schellenberger, M.T.; Bock, U.; Hennen, J.; Gröber-Becker, F.; Walles, Heike; Blömeke, B.
Abstract
2018Possible benefits of ultra high field MRI in cardiac diffusion tensor imaging
Lohr, D.; Terekhov, M.; Weng, A.M.; Schroeder, D.; Walles, Heike; Schreiber, L.M.
Abstract
2018Rapid analysis of cell-nanoparticle interactions using single-cell raman trapping microscopy
Steinke, Maria; Zunhammer, Florian; Chatzopoulou, Elisavet I.; Teller, Henrik; Schütze, Karin; Walles, Heike; Rädler, Joachim O.; Grüttner, Cordula
Zeitschriftenaufsatz
2018Recombinant collagen I peptide microcarriers for cell expansion and their potential use as cell delivery system in a bioreactor model
Suarez Muñoz, Melva; Confalonieri, Davide; Walles, Heike; Dongen, Elisabeth M.W.M. van; Dandekar, Gudrun
Zeitschriftenaufsatz
2018Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation
Lotz, Christian; Kiesewetter, L.; Schmid, Freia F.; Hansmann, Jan; Walles, Heike; Groeber-Becker, Florian Kai
Zeitschriftenaufsatz
2018Site-directed immobilization of bone morphogenetic protein 2 to solid surfaces by click chemistry
Siverino, Claudia; Tabisz, Barbara; Lühmann, Tessa; Meinel, Lorenz; Müller, Thomas D.; Walles, Heike; Nickel, Joachim
Zeitschriftenaufsatz
2018A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation
Schmid, Freia F.; Groeber-Becker, Florian; Schwab, Stefanie; Thude, Sibylle; Goebeler, Matthias; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2018Stem cell-based human blood-brain barrier co-culture models for pre-clinical development
Appelt-Menzel, Antje; Cubukova, Alevtina; Piontek, Jörg; Walles, Heike; Neuhaus, Winfried; Metzger, Marco
Zeitschriftenaufsatz, Konferenzbeitrag
2018Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds
Stuckensen, Kai; Schwab, Andrea; Knauer, Markus; Muiños-López, Emma; Ehlicke, Franziska; Reboredo, Jenny W.; Granero-Moltó, Froilán; Gbureck, Uwe; Prósper, Felipe; Walles, Heike; Groll, Jürgen
Zeitschriftenaufsatz
2018The use of a THP-1/3D reconstructed human epidermis (RHE) coculture system to assess the sensitizing potential of chemicals
Schellenberger, M.T.; Bock, U.; Hennen, J.; Groeber-Becker, Florian Kai; Walles, Heike; Blömeke, B.
Abstract
2017Calcium fluoride based multifunctional nanoparticles for multimodal imaging
Straßer, Marion; Schrauth, Joachim H.X.; Dembski, Sofia; Haddad, Daniel; Ahrens, Bernd; Schweizer, Stefan; Christ, Bastian; Cubukova, Alevtina; Metzger, Marco; Walles, Heike; Jakob, Peter M.; Sextl, Gerhard
Zeitschriftenaufsatz
2017A comparative multi-parametric in vitro model identifies the power of test conditions to predict the fibrotic tendency of a biomaterial
Jannasch, Maren; Gätzner, Sabine; Weigel, Tobias; Walles, Heike; Schmitz, Tobias; Hansmann, Jan
Zeitschriftenaufsatz
2017Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluri- and multipotent stem cells
Appelt-Menzel, Antje; Cubukova, Alevtina; Günther, Katharina; Edenhofer, Frank; Piontek, Jörg; Krause, Gerd; Stüber, Tanja; Walles, Heike; Neuhaus, Winfried; Metzger, Marco
Zeitschriftenaufsatz
2017Human barrier models for the in vitro assessment of drug delivery
Schweinlin, Matthias; Rossi, Angela; Lodes, Nina; Lotz, Christian; Hackenberg, Stephan; Steinke, Maria; Walles, Heike; Groeber, Florian
Zeitschriftenaufsatz
2017In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction
Jannasch, Maren; Weigel, Tobias; Engelhardt, Lisa; Wiezoreck, Judith; Gaetzner, Sabine; Walles, Heike; Schmitz, Tobias; Hansmann, Jan
Zeitschriftenaufsatz
2017A multilayered electrospun graft as vascular access for hemodialysis
Radakovic, Dejan; Reboredo, Jenny W.; Helm, M.; Weigel, Tobias; Schürlein, Sebastian; Kupczyk, E.; Leyh, Rainer G.; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2017A pancreas‐specific ECM scaffold – human iPS cell culture and pancreatic differentiation goes 3D
Berger, Constantin; Bjørlykke, Yngvild; Mühlemann, Markus; Ræder, Helge; Walles, Heike; Metzger, Marco; Zdzieblo, Daniela
Abstract
2017Screening applications to test cellular fitness in transwell® models after nanoparticle treatment
Christ, Bastian; Fey, Christina; Cubukova, Alevtina; Walles, Heike; Dembski, Sofia; Metzger, Marco
Aufsatz in Buch
2017Tissue Engineering of primary human in vitro models – Influence of mechanical and biochemical stimulation on tissue functionality
Appelt-Menzel, Antje; Zdzieblo, Daniela; Schürlein, Sebastian; Schwarz, Thomas; Hansmann, Jan; Metzger, Marco; Walles, Heike
Abstract
2017A versatile modular bioreactor platform for Tissue Engineering
Schürlein, Sebastian; Schwarz, Thomas; Krziminski, Steffan; Gätzner, Sabine; Hoppensack, Anke; Schwedhelm, Ivo; Schweinlin, Matthias; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
20163D in vitro tissue models for infection studies with human pathogens
Schweinlin, Matthias; Steinke, Maria; Groeber, Florian; Gross, Roy; Reuter, Christian; Seidensticker, Katharina; Schulte, Leon; Metzger, Marco; Engstler, Markus; Walles, Heike
Abstract
2016Alternative methods for the replacement of eye irritation testing
Lotz, Christian; Schmid, Freia F.; Rossi, Angela; Kurdyn, Szymon; Kampik, Daniel; Wever, Bart de; Walles, Heike; Groeber, Florian
Zeitschriftenaufsatz
2016ATERA: Advanced 3D human tissue models and exclusive testing services for cosmetic, consumer product and pharmaceutical industry
Wever, Bart de; Varlet, Beatrice le; Groeber, Florian; Ginosian, Anna; Guillon, Fabien; Walles, Heike
Abstract
2016BioVaSc-TERM - a platform technology to engineer human barrier models
Rossi, Angela; Schweinlin, Matthias; Steinke, Maria; Groeber, Florian; Walles, Heike
Abstract
2016Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase II)
Groeber, Florian; Schober, Lena; Schmid, Freia F.; Traube, Andrea; Kolbus-Hernandez, Silvia; Daton, K.; Hoffmann, Sebastian; Petersohn, Dirk; Schäfer-Korting, Monika; Walles, Heike; Mewes, Karsten R.
Zeitschriftenaufsatz
2016A combined 3D tissue engineered in Vitro/in silico lung tumor model for predicting drug effectiveness in specific mutational backgrounds
Göttlich, Claudia; Müller, Lena C.; Kunz, Meik; Schmitt, Franziska; Walles, Heike; Walles, Thorsten; Dandekar, Thomas; Dandekar, Gudrun; Nietzer, Sarah L.
Zeitschriftenaufsatz
2016Complex skin models and impedance spectroscopy as new tools for hazard identification and efficacy testing
Groeber, Florian; Engelhardt, Lisa; Guillon, Fabien; Varlet, Beatrice le; Wever, Bart de; Walles, Heike
Abstract
2016Development of an advanced primary human in vitro model of the small intestine
Schweinlin, Matthias; Wilhelm, Sabine; Schwedhelm, Ivo; Hansmann, Jan; Rietscher, Rene; Jurowich, Christian; Walles, Heike; Metzger, Marco
Zeitschriftenaufsatz
2016Differential regulation of SOX9 protein during chondrogenesis of induced pluripotent stem cells versus mesenchymal stromal cells: A shortcoming for cartilage formation
Diederichs, Solvig; Gabler, Jessica; Autenrieth, Jennifer; Kynast, Katharina L.; Merle, Christian; Walles, Heike; Utikal, Jochen; Richter, Wiltrud
Zeitschriftenaufsatz
2016Evaluation of various bioreactor process systems for the production of induced pluripotent stem cells
Appelt-Menzel, Antje; Schwedhelm, Ivo; Kühn, Fabian; Cubukova, Alevtina; Edenhofer, Frank; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2016A first vascularized skin equivalent for as an alternative to animal experimentation
Groeber, Florian; Engelhardt, Lisa; Lange, Julia; Kurdyn, Szymon; Schmid, Freia F.; Rücker, Christoph; Mielke, Stephan; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2016Human organotypic lung tumor models: Suitable for preclinical 18F-FDG PET-imaging
Fecher, David; Hofmann, Elisabeth; Buck, Andreas; Bundschuh, Ralph; Nietzer, Sarah; Dandekar, Gudrun; Walles, Thorsten; Walles, Heike; Lückerath, Katharina; Steinke, Maria
Zeitschriftenaufsatz
2016Hybrid cell detachment-free cell expansion system for adherent cell culturing and related proceeding protocol
Confalonieri, Davide; Hansmann, Jan; Walles, Heike; Krziminski, Steffan
Patent
2016Investigation of migration and differentiation of human mesenchymal stem cells on five-layered collagenous electrospun scaffold mimicking native cartilage structure
Reboredo, Jenny; Weigel, Tobias; Steinert, Andre; Rackwitz, Lars; Rudert, Maximilian; Walles, Heike
Zeitschriftenaufsatz
2016Isotropic versus bipolar functionalized biomimetic artificial basement membranes and their evaluation in long-term human cell co-culture
Rossi, Angela; Wistlich, Laura; Heffels, Karl-Heinz; Walles, Heike; Groll, Jürgen
Zeitschriftenaufsatz
2016Mimicking metastases including tumor stroma: A new technique to generate a three-dimensional colorectal cancer model based on a biological decellularized intestinal scaffold
Nietzer, Sarah; Baur, Florentin; Sieber, Stefan; Hansmann, Jan; Schwarz, Thomas; Stoffer, Carolin; Häfner, Heide; Gasser, Martin; Waaga-Gasser, Ana Maria; Walles, Heike; Dandekar, Gudrun
Zeitschriftenaufsatz
2016Monitoring der Substanzwirkung bei in vitro Geweben
Groeber, Florian; Hansmann, Jan; Walles, Heike
Patent
2016Rapid monolayer neural induction of induced pluripotent stem cells yields stably proliferating neural stem cells
Günther, Katharina; Appelt-Menzel, Antje; Kwok, Chee Keong; Walles, Heike; Metzger, Marco; Edenhofer, Frank
Zeitschriftenaufsatz
2016Recent developments of disease and human in vitro models of the blood-brain barrier
Appelt-Menzel, Antje; Piontek, Jörg; Kraemer, Tobias; Riethmüller, Christoph; Gaiser, Fabian; Neuhoff, Anja; Mahringer, Anne; Thal, Serge; Förster, Carola; Walles, Heike; Metzger, Marco; Neuhaus, Winfried
Abstract
2016Stem cell labeling with iron oxide nanoparticles: Impact of 3D culture on cell labeling maintenance
Kilian, Teresa; Fidler, Florian; Kasten, Annika; Nietzer, Sarah; Landgraf, Veronika; Weiß, Katrin; Walles, Heike; Westphal, Fritz; Hackenberg, Stephan; Grüttner, Cordula; Steinke, Maria
Zeitschriftenaufsatz
2016Strategies and first advances in the development of prevascularized bone implants
Rücker, Christoph; Kirch, Holger; Pullig, Oliver; Walles, Heike
Zeitschriftenaufsatz
2016Tissue Engineering 4.0
Walles, Heike
Zeitschriftenaufsatz, Konferenzbeitrag
2015Development of an improved primary in vitro model of the human small intestine
Schweinlin, Matthias; Wilhelm, Sabine; Walles, Heike; Metzger, Marco
Konferenzbeitrag, Zeitschriftenaufsatz
2015Ex vivo osteo-chondral organ culture
Schwab, Andrea; Ehlicke, Franziska; Hansmann, Jan; Walles, Heike
Zeitschriftenaufsatz
2015Generation of a three-dimensional full thickness skin equivalent and automated wounding
Rossi, Angela; Appelt-Menzel, Antje; Kurdyn, Szymon; Walles, Heike; Groeber, Florian
Zeitschriftenaufsatz
2015Host-integration of a tissue-engineered airway patch: Two-year follow-up in a single patient
Steinke, Maria; Dally, Iris; Friedel, Godehard; Walles, Heike; Walles, Thorsten
Zeitschriftenaufsatz
2015Influence of hematopoietic components of the bone marrow on in vitro bone formation assays
Confalonieri, Davide; Ehlicke, Franziska; Walles, Heike
Konferenzbeitrag, Zeitschriftenaufsatz
2015A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects
Kleinhans, Claudia; Mohan, Ramkumar Ramani; Vacun, Gabriele; Schwarz, T.; Haller, B.; Sun, Yang; Kahlig, A.; Kluger, Petra; Finne-Wistrand, Anna.; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2015Physiological impact of odorants: Immediate versus post-ingestion and post-inhalation effects
Buettner, A.; Beauchamp, J.; Freiherr, Jessica; Heinlein, Anja; Kessler, Artur; Leuner, Kristina; Metzger, Marco; Pischetsrieder, Monika; Villmann, Carmen; Walles, Heike
Konferenzbeitrag
2015Pre-vascularized bone implant composed of cell-seeded naturally derived collagen matrix and synthetic ß-TCP
Rücker, Christoph; Henkel, J.; Stigler, R.G.; Hutmacher, Dietmar W.; Rasse, M.; Walles, Heike
Zeitschriftenaufsatz, Konferenzbeitrag
2015Self organizing vascularized cardiac scaffolds from human atrial appendages
Beck, Carolin; Werner, Martina; Walles, Heike; Leistner, Marcus
Konferenzbeitrag, Zeitschriftenaufsatz
2015Site-directed immobilization of BMP-2 and Noggin inhibitory peptides onto collagen beads for bone regeneration
Siverino, Claudia; Nickel, Joachim; Walles, Heike
Konferenzbeitrag, Zeitschriftenaufsatz
2015Study of the effect of collagenous microcarriers on the vasculogenic potential of endothelial cells obtained from different sources
Suarez Munoz, M.; Dandekar, Gudrun; Walles, Heike
Konferenzbeitrag, Zeitschriftenaufsatz
2015Two-photon polymerization of inorganic-organic polymers for biomedical and microoptical applications
Burmeister, Frank; Steenhusen, Sönke; Houbertz, Ruth; Asche, T.S.; Nickel, J.; Nolte, Stefan; Tucher, Nico; Josten, P.; Obel, Kerstin; Wolter, Herbert; Fessel, S.; Schneider, A.M.; Gärtner, K.-H.; Beck, C.; Behrens, P.; Tünnermann, Andreas; Walles, Heike
Aufsatz in Buch
2014Development of nanoelectrodes for cell stimulation and reduced foreign body reaction
Weigel, Tobias; Schmitz, T.; Jannasch, Maren; Gätzner, S.; Walles, Heike; Hansmann, Jan
Abstract
2014Next generation tissue models as a replacement for animal experiments
Groeber, Florian; Schmid, Franziska; Schober, Lena; Traube, Andrea; Walles, Heike
Abstract
2014Organ-like three dimensional test systems
Rossi, Angela; Groeber, Florian; Steinke, Maria; Dandekar, Gudrun; Nietzer, Sarah; Metzger, Marco; Walles, Heike
Abstract
2014The role of enteric glial cells in inflammatory diseases of the bowel
Moll, Corinna; Heider, A.; Brede, Christian; Scholz, Claus-Jürgen; Cecil, Alexander; Walles, Heike; Metzger, Marco
Abstract
2013Editorial: Strategies in tissue engineering and regenerative medicine
Schenke-Layland, Katja; Walles, Heike
Zeitschriftenaufsatz
2013An in vitro model of the renal proximal tubule composed of small intestinal submucosa (SIS) and human kidney-derived cells (hKDCs)
Hoppensack, Anke; Schanz, Johanna; Kazanecki, Christian; Colter, David; Walles, Heike
Zeitschriftenaufsatz, Konferenzbeitrag
2013Upcyte(R). Microvascular endothelial cells repopulate decellularized scaffold
Scheller, Katharina; Dally, Iris; Hartmann, Nadja; Münst, Bernhard; Braspenning, Joris; Walles, Heike
Zeitschriftenaufsatz
2012Automatic image quantification for structural analysis of in vitro dermal samples
Gryanik, Alexander; Wittenberg, Thomas; Walles, Heike; Steckhan, Dirk; Thude, Sibylle; Kaufmann, Michaela; Münzenmayer, Christian
Konferenzbeitrag, Zeitschriftenaufsatz
2012Design of a compact multi-sensor system for non-invasive glucose monitoring using optical spectroscopy
Abdallah, Omar; Bolz, Armin; Hansmann, Jan; Walles, Heike; Hirth, Thomas
Konferenzbeitrag
2012Development of full-thickness skin equivalents including immunological cell types
Kurdyn, Szymon; Weil, Frederick; Nickel, Joachim; Mielke, Stephan; Walles, Heike
Abstract
2011Artificial small diameter blood vessels based on new biofunctionalized 3D-printable polymers
Novosel, Esther; Klechowitz, Nadine; Meyer, Wolfdietrich; Schuh, Christian; Borchers, Kirsten; Wegener, Michael; Krüger, Hartmut; Walles, Heike; Hirth, Thomas; Tovar, Günter; Kluger, Petra
Zeitschriftenaufsatz, Konferenzbeitrag
2011Diamond containing scaffolds
Steinmüller-Nethl, Doris; Walles, Heike
Patent
2011Vollautomatisierte Herstellung von Gewebemodellen
Walles, Heike
Zeitschriftenaufsatz