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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar, Z.; Östling, J.; Ax, E.; Calven, J.; Thörn, K.; Israelsson, E.; Öberg, L.; Singhania, A.; Lau, L.C.K.; Wilson, S.J.; Ward, J.A.; Chauhan, A.; Sousa, A.R.; Meulder, B. de; Loza, M.J.; Baribaud, F.; Sterk, P.J.; Chung, K.F.; Sun, K.; Guo, Y.; Adcock, I.M.; Payne, D.; Dahlen, B.; Chanez, P.; Shaw, D.E.; Krug, Norbert; Hohlfeld, Jens M.; Sandström, T.; Djukanovic, R.; James, A.; Hinks, T.S.C.; Howarth, P.H.; Vaarala, O.; Geest, M. van; Olsson, H.; Adcock, I.M.; Ahmed, H.; Auffray, C.; Bakke, P.; Bansal, A.T.; Baribaud, F.; Bates, S.; Bel, E.H.; Bigler, J.; Bisgaard, H.; Boedigheimer, M.J.; Bonnelykke, K.; Brandsma, J.; Brinkman, P.; Bucchioni, E.; Burg, D.; Bush, A.; Caruso, M.; Chaiboonchoe, A.; Chanez, P.; Chung, F.K.; Compton, C.H.; Corfield, J.; D'Amico, A.; Dahlen, S.E.; De Meulder, B.; Djukanovic, R.; Erpenbeck, V.J.; Erzen, D.; Fichtner, K.; Fitch, N.; Fleming, L.J.; Formaggio, E.; Fowler, S.J.; Frey, U.; Gahlemann, M.; Geiser, T.; Goss, V.; Guo, Y.; Hashimoto, S.; Haughney, J.; Hedlin,
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2019Treatable traits in the European U-BIOPRED adult asthma cohorts
Simpson, A.J.; Hekking, P.-P.; Shaw, D.E.; Fleming, L.J.; Roberts, G.; Riley, J.H.; Bates, S.; Sousa, A.R.; Bansal, A.T.; Pandis, I.; Sun, K.; Bakke, P.S.; Caruso, M.; Dahlen, B.; Dahlen, S.-E.; Horvath, I.; Krug, N.; Montuschi, P.; Sandstrom, T.; Singer, F.; Adcock, I.M.; Wagers, S.S.; Djukanovic, R.; Chung, K.F.; Sterk, P.J.; Fowler, S.J.; Hohlfeld, J.M. et al.
Zeitschriftenaufsatz
2018Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort
Emma, Rosalia; Bansal, Aruna T.; Kolmert, Johan; Wheelock, Craig E.; Dahlén, Sven-Erik; Loza, Matthew J.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Dahlén, Barbro; Bakke, Per S.; Chanez, Pascal; Fowler, Stephen J.; Horvath, Ildiko; Montuschi, Paolo; Krug, Norbert; Sanak, Marek; Sandström, Thomas; Shaw, Dominick E.; Fleming, Louise J.; Djukanovic, Ratko; Howarth, Peter H.; Singer, Florian; Sousa, Ana R.; Sterk, Peter J.; Corfield, Julie; Pandis, Ioannis; Chung, Kian F.; Adcock, Ian M.; Lutter, René; Fabbella, Lorena; Caruso, Massimo
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2018Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome
Burg, Dominic; Schofield, James P.R.; Brandsma, Joost; Staykova, Doroteya; Folisi, Caterina; Bansal, Aruna T.; Nicholas, Ben; Xian, Yang; Rowe, Anthony; Corfield, Julie; Wilson, Susan J.; Ward, Jonathan A.; Lutter, René; Fleming, Louise; Shaw, Dominick E.; Bakke, Per S.; Caruso, Massimo; Dahlén, Sven-Erik; Fowler, Stephen J.; Hashimoto, Simone; Horvath, Ildiko; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Singer, Florian; Sun, Kai; Pandis, Ioannis; Auffray, Charles; Sousa, Ana R.; Adcock, Ian M.; Chung, Kian F.; Sterk, Peter J.; Djukanovic, Ratko; Skipp, Paul J.
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2018Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers
Brandsma, Joost; Goss, Victoria M.; Yang, Xian; Bakke, Per S.; Caruso, Massimo; Chanez, Pascal; Dahlén, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Shaw, Dominick E.; Chung, Kian Fan; Singer, Florian; Fleming, Louise J.; Sousa, Ana R.; Pandis, Ioannis; Bansal, Aruna T.; Sterk, Peter J.; Djukanović, Ratko; Postle, Anthony D.
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2018Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort
Alahmadi, Fahad; Simpson, Andrew; Gomez, Christina; Wheelock, Craig; Shaw, Dominick E.; Fleming, Louise; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R.; Knowles, Richard; Bansal, Aruna T.; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per; Caruso, Massimo; Chanez, Pascal; Dahlen, Babro; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sandstrom, Thomas; Singer, Florian; Wagers, Scott; Adcock, Ian M.; Djukanović, Ratko; Chung, Kian Fan; Sterk, Peter J.; Dahlén, Sven-Erik; Fowler, Stephen J.
Abstract
2018Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: An exploratory analysis
Takahashi, Kentaro; Pavlidis, Stelios; Ng Kee Kwong, Francois; Hoda, Uruj; Rossios, Christos; Sun, Kai; Loza, Matthew; Baribaud, Fred; Chanez, Pascal; Fowler, Steve J.; Horvath, Ildiko; Montuschi, Paolo; Singer, Florian; Musial, Jacek; Dahlén, Barbro; Dahlén, Sven-Erik; Krug, Norbert; Sandström, Thomas; Shaw, Dominick E.; Lutter, René; Bakke, Per; Fleming, Louise J.; Howarth, Peter H.; Caruso, Massimo; Sousa, Ana R.; Corfield, Julie; Auffray, Charles; Meulder, Bertrand de; Lefaudeux, Diane; Djukanovic, Ratko; Sterk, Peter J.; Guo, Yike; Adcock, Ian M.; Chung, Kian Fan
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2018Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA
Schofield, James P.R.; Bigler, Jeanette; Boedigheimer, Michael; Affleck, Karen; Taylor, Adam; Pavlidis, Stelios; Riley, John H.; Strazzeri, Fabio; Roberts, Graham; Brandsma, Joost; Bansal, Aruna T.; Nicholas, Ben; Xian, Yang; Rowe, Anthony; Corfield, Julie; Wilson, Susan J.; Ward, Jonathan A.; Lutter, René; Fleming, Louise; Shaw, Dominick E.; Per, Bakke; Caruso, Massimo; Dahlén, Sven-Erik; Fowler, Stephen J.; Hashimoto, Simone; Horváth, Ildikó; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandstrom, Thomas; Singer, Florian; Sun, Kai; Pandis, Ioannis; Auffray, Charles; Meulder, Bertrand de; Lefaudeux, Diane; Knowles, Richard; Fitch, Neil; Sousa, Ana R.; Adcock, Ian M.; Chung, Kian Fan; Sterk, Peter J.; Skipp, Paul; Djukanović, Ratko
Abstract
2018U-BIOPRED accessible handprint: Combining omics platforms to identify stable asthma subphenotypes
Meulder, Bertrand de; Yen, Romain Tching Chi; Li, Chuan-Xing; Wheelock, Asa; Chung, Kian Fan; Adcock, Ian M.; Djukanović, Ratko; Wagers, Scott; Riley, John; Erpenbeck, Veit J.; Bakke, Per; Caruso, Massimo; Chanez, Pascal; Dahlén, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Shaw, Dominic; Singer, Florian; Pandis, Ioannis; Bansal, Aruna T.; Sterk, Peter J.; Baribaud, Frédéric; Auffray, Charles
Abstract
2017U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
Lefaudeux, D.; De Meulder, B.; Loza, M.J.; Peffer, N.; Rowe, A.; Baribaud, F.; Bansal, A.T.; Lutter, R.; Sousa, A.R.; Corfield, J.; Pandis, I.; Bakke, P.S.; Caruso, M.; Chanez, P.; Dahlén, S.-E.; Fleming, L.J.; Fowler, S.J.; Horvath, I.; Krug, N.; Montuschi, P.; Sanak, M.; Sandstrom, T.; Shaw, D.E.; Singer, F.; Sterk, P.J.; Roberts, G.; Adcock, I.M.; Djukanovic, R.; Auffray, C.; Chung, K.F.
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2016Influence of post-hydrogenation upon electrical, optical and structural properties of hydrogen-less sputter-deposited amorphous silicon
Gerke, S.; Becker, H.W.; Rogalla, D.; Singer, F.; Brinkmann, N.; Fritz, S.; Hammud, A.; Keller, P.; Skorka, D.; Sommer, D.; Weiss, C.; Flege, S.; Hahn, G.; Job, R.; Terheiden, B.
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2015Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Shaw, Dominick E.; Sousa, Ana R.; Fowler, Stephen J.; Fleming, Louise J.; Roberts, Graham; Corfield, Julie; Pandis, Ioannis; Bansal, Aruna T.; Bel, Elisabeth H.; Auffray, Charles; Compton, Chris H.; Bisgaard, Hans; Bucchioni, Enrica; Caruso, Massimo; Chanez, Pascal; Dahlén, Barbro; Dahlén, Sven-Erik; Dyson, Kerry; Frey, Urs; Geiser, Thomas; Gerhardsson de Verdier, Maria; Gibeon, David; Guo, Yi-Ke; Hashimoto, Simone; Hedlin, Gunilla; Jeyasingham, Elizabeth; Hekking, Pieter-Paul W.; Higenbottam, Tim; Horváth, Ildikó; Knox, Alan J.; Krug, Norbert; Erpenbeck, Veit J.; Larsson, Lars X.; Lazarinis, Nikos; Matthews, John G.; Middelveld, Roelinde; Montuschi, Paolo; Musial, Jacek; Myles, David; Pahus, Laurie; Sandström, Thomas; Seibold, Wolfgang; Singer, Florian; Strandberg, Karin; Vestbo, Jorgen; Vissing, Nadja; Garnier, Christophe von; Adcock, Ian M.; Wagers, Scott; Rowe, Anthony; Howarth, Peter; Wagener, Ariane H.; Djukanovic, Ratko; Sterk, Peter J.; Chung, Kian Fan
Zeitschriftenaufsatz
2015The first U-BIOPRED blood handprint of severe asthma
Meulder, B. de; Lefaudeux, D.; Bigler, J.; Loza, M.J.; Wheelock, C.E.; Sousa, A.R.; Corfield, J.; Baribaud, F.; Auffray, C.; Shaw, D.E.; Horvath, I.; Musial, J.; Chanez, P.; Krug, N.; Montuschi, P.; Bakke, P.S.; Singer, F.; Fowler, S.J.; Dahlen, S.E.; Sandström, T.; Sterk, P.J.; Chung, K.F.; Adcock, I.M.; Djukanovic, R.
Abstract
2015The first U-BIOPRED sputum handprint of severe asthma
Lefaudeux, D.; Meulder, B. de; Loza, M.J.; Sanak, M.; Sousa, A.R.; Corfield, J.; Baribaud, F.; Shaw, D.E.; Horvath, I.; Musial, J.; Chanez, P.; Krug, N.; Montuschi, P.; Bakke, P.S.; Singer, F.; Fowler, S.J.; Dahlen, S.E.; Sandström, T.; Sterk, P.J.; Djukanovic, R.; Chung, K.F.; Adcock, I.M.; Auffray, C.
Abstract
2015Prevalence Of Gastro-Oesophageal Reflux (GORD) And Associations With Clinical Phenotypic Markers In Adult Severe Asthmatics In The U-Biopred Cohort
Tariq, K.; Nicholas, B.L.; Lutter, R.; Bel, E.; Bansal, A.; Wagers, S.S.; Bisgaard, H.; Sandström, T.; Larsson, L.; Vestbo, J.; Montuschi, P.; Higgenbottam, T.W.; Compton, C.; Myles, D.; Chanez, P.; Pahus, L.; Murray, C.S.; Woodcock, A.; Musial, J.; Nordlund, B.; Hashimoto, S.; Hedlin, G.L.; Dahlen, S.E.K.; Middelveld, R.; Dahlen, B.; Krug, N.; Vissing, N.; Polosa, R.; Horvath, I.; Singer, F.; Bakke, P.; Roberts, G.; Fichtner, K.; Rowe, A.; Jeyasingham, E.; Riley, J.; Fleming, L.; Fowler, S.J.; Shaw, D.E.; Corfield, J.; Sousa, A.R.; Chung, K.; Howarth, P.H.; Sterk, P.J.; Djukanovic, R.
Abstract
2014Prevalence and phenotypic characteristics of severe adult-onset asthma in the U-Biopred cohort
Hekking, Pieter-Paul; Wagener, Ariane H.; Sousa, Ana R.; Fowler, Stephen J.; Bakke, Per; Frey, Urs; Krug, Norbert; Hashimoto, Simone; Woodcock, Ashley; Chanez, Pascal; Montuschi, Paolo; Bisgaard, Hans; Corfield, Julie; Howarth, Peter H.; Djukanovic, Ratko; Chung, Kian Fan; Fleming, Louise; Riley, John; Jeyasingham, Elisabeth; Fichtner, Klaus; Rowe, Anthony; Roberts, Graham; Singer, Florian; Geiser, Thomas; Horvath, Ildiko; Riccardo, Polosa; Vissing, Nadja H.; Dahlen, Babro; Musial, Jacek; Murray, Clare S.; Myles, David; Compton, Chris; Higenbottam, Tim W.; Vestbo, J.; Pahus, Laurie; Larsson, Lars; Sandstrom, Thomas; Shaw, Dominic; Wagers, Scott S.; Sterk, Peter J.; Bansal, Aruna T.; Bel, Elisabeth
Abstract
2011Acetylene measurement using quantum cascade lasers at 14 µm
Herbst, J.; Scherer, B.; Singer, F.; Erb, J.; Lambrecht, A.; Rathke, C.; Filip, S.; Kappler, J.; Fuchst, P.; Koeth, J.; Friedl, J.; Schlereth, T.W.; Semmel, J.; Höfling, S.
Vortrag
2011Acetylene measurement using quantum cascade lasers at 14 µm
Herbst, J.; Scherer, B.; Singer, F.; Erb, J.; Lambrecht, A.; Rathke, C.; Filip, S.; Kappler, J.; Fuchs, P.; Koeth, J.; Friedl, J.; Schlereth, T.W.; Semmel, J.; Höfling, S.; Worschesch, L.; Forchel, A.
Konferenzbeitrag
2007Montage von Mikrooptiken für mobile DVD Laufwerke
Mohaupt, M.; Beckert, E.; Eberhardt, R.; Tünnermann, A.; Knittel, J.; Steegmueller, U.; Behringer, M.; Singer, F.; Schwarz, T.
Konferenzbeitrag