Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Acute inhalation toxicity in vitro and ex vivo test battery prior to regulatory OECD 403 studies
Schwarz, Katharina; Hansen, Tanja; Ritter, Detlef; Walter, Dorothee; Knebel, Jan
Abstract
2018Air-liquid interface in vitro models for respiratory toxicology research: Consensus workshop and recommendations
Lacroix, Ghislaine; Koch, Wolfgang; Ritter, Detlef; Gutleb, Arno C.; Larsen, Søren Thor; Loret, Thomas; Zanetti, Filippo; Constant, Samuel; Chortarea, Savvina; Rothen-Rutishauser, Barbara M.; Hiemstra, Pieter S.; Frejafon, Emeric; Hubert, Philippe; Gribaldo, Laura; Kearns, Peter; Aublant, Jean-Marc; Diabaté, Silvia; Weiss, Carsten; Groot, Antoinette de; Kooter, Ingeborg
Zeitschriftenaufsatz
2018A combination of in-vitro and ex-vivo test models as an upstream alternative to regulatory OECD 403 animal studies
Walter, Dorothee; Ritter, Detlef; Knebel, Jan; Schwarz, Katharina; Hansen, Tanja
Abstract
2018Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test system
Knebel, Jan W.; Ritter, Detlef; Niehof, Monika; Hansen, Tanja; Strandh, M.; Falciani, C.; Flores, M.; Welscher, Y. te; Nostrum, C. van; Gracia, R.; Marradi, M.; Loinaz, I.
Abstract
2018Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process
Ritter, Detlef; Bitsch, Annette; Elend, Manfred; Schuchardt, Sven; Hansen, Tanja; Brodbeck, Carsten; Knebel, Jan; Fuchs, Anne; Gronewold, Claas; Fautz, Rolf
Zeitschriftenaufsatz
2018Early biomarkers indicating COPD can be induced by whole cigarette smoke in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Zardo, Patrick; Fieguth, Hans-Gerd; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2017Applying CFD for the Design of an Air-Liquid Interface In-Vitro Testing Method for Inhalable Compounds
Brodbeck, Carsten; Knebel, Jan; Ritter, Detlef; Wolf, Klaus
Aufsatz in Buch
2016Expositionsvorrichtung
Brodbeck, Carsten; Ritter, Detlef; Knebel, Jan; Wolf, Klaus
Patent
2015Acute inhalation toxicity of volatile organic compounds - application of an improved cell-based in vitro procedure
Ritter, Detlef; Krakor, E.; Knebel, Jan
Abstract
2015Acute toxicity testing of inhalable/gaseous compounds by cell-based methods in vitro - application to volatile organic compounds
Ritter, Detlef; Knebel, Jan
Abstract
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices
Obernolte, Helena; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Expositionsapparat
Ritter, Detlef; Knebel, Jan
Patent
2014Biological effects of inhalable compounds improvements of the in vitro testing method
Ritter, Detlef; Knebel, Jan; Brodbeck, Carsten; Javala, Pasi
Abstract
2014Biological effects of inhalable substances - development of a concept to standardize in vitro studies using aerosols
Ritter, Detlef; Arndt, Hendrik; Knebel, Jan
Zeitschriftenaufsatz, Konferenzbeitrag
2014Building up a co-culture and surfactant model for routine use in ali exposures
Javala, Pasi; Ritter, Detlef; Knebel, Jan
Abstract
2014Fundamental improvements of the air-liquid interface technique for use in in vitro inhalation toxicology
Knebel, Jan; Ritter, Detlef; Brodbeck, Carsten
Abstract
2014Improvements of the ALI in vitro testing method for inhalable compounds
Ritter, Detlef; Knebel, Jan; Brodbeck, Carsten
Abstract
2014Investigations of the biological effects of airborne and inhalable substances by cell-based in vitro methods
Ritter, Detlef; Knebel, Jan
Zeitschriftenaufsatz
2014Validation requirements for alternative methods in inhalation toxicology - case study of a German two phase prevalidation project
Liebsch, M.; Pirow, R.; Smirnova, L.; Tharmann, J.; Linsel, G.; Troeller, S.; Huettig, N.; Bauer, M.; Graebsch, C.; Berger-Preiß, Edith; Kock, Heiko; Oertel, Antje; Ritter, Detlef; Knebel, Jan
Abstract
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz
2012Acute cigarette smoke exposure induces cytotoxicity and inflammation in living tissue of precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Ritter, Detlef; Knebel, Jan; Dasenbrock, Clemens; Braun, Armin; Sewald, Katherina
Abstract
2011Discrepancy between high clastogenic activity of trans-beta-nitrostyrene in vitro and lack in carcinogenicity might be related to inactivating metabolism and its high reactivity towards thiol groups
Ziemann, Christina; Apitius, Florian; Elend, Manfred; Baumgartner, S.; Volk, J.; Ritter, Detlef; Steinfelder, H.J.; Schuchardt, Sven
Konferenzbeitrag, Zeitschriftenaufsatz
2011Improvement of experimental methods for toxicological characterization of inhalable substances in vitro by in situ analysis of the cellular status based on fluorescence stainings
Ritter, Detlef; Knebel, Jan
Konferenzbeitrag, Zeitschriftenaufsatz
2011Prävalidierungsstudie zur Prüfung der toxischen Wirkung von inhalativ wirksamen Stoffen (Gase)
Knebel, Jan; Ritter, Detlef; Berger-Preiß, Edith; Kock, Heiko; Liebsch, Manfred; Smirnova, Lena; Pirow, Ralph; Linsel, Gunter; Bauer, Mario; Graebsch, Carolin
Studie
2011Toxicological characterization of inhalable substances and aerosols in vitro: Enhancement of experimental methods by in situ fluorescence analysis of the cellular status during exposure
Ritter, Detlef; Knebel, Jan
Zeitschriftenaufsatz, Konferenzbeitrag
2011Untersuchungen zum biologischen Effekt inhalierbarer Aerosole in vitro
Lange, Carsten
: Scharfenberg, Klaus (Erstprüfer); Dasenbrock, Clemens (Zweitprüfer); Knebel, Jan (Betreuer); Ritter, Detlef (Betreuer)
Bachelor Thesis