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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2021A Drug Repositioning Approach Identifies a Combination of Compounds as a Potential Regimen for Chronic Lymphocytic Leukemia Treatment
Nehdi, A.; Samman, N.; Mashhour, A.; Alhallaj, A.; Trivilegio, T.; Gul, S.; Reinshagen, J.; Alaskar, A.; Gmati, G.; Abuelgasim, K.A.; Mansour, F.; Boudjelal, M.
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2021Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen
Kuzikov, M.; Costanzi, E.; Reinshagen, J.; Esposito, F.; Vangeel, L.; Wolf, M.; Ellinger, B.; Claussen, C.; Geisslinger, G.; Corona, A.; Iaconis, D.; Talarico, C.; Manelfi, C.; Cannalire, R.; Rossetti, G.; Gossen, J.; Albani, S.; Musiani, F.; Herzog, K.; Ye, Y.; Giabbai, B.; Demitri, N.; Jochmans, D.; Jonghe, S.D.; Rymenants, J.; Summa, V.; Tramontano, E.; Beccari, A.R.; Leyssen, P.; Storici, P.; Neyts, J.; Gribbon, P.; Zaliani, A.
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2021A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization
Schultz, B.; Zaliani, A.; Ebeling, C.; Reinshagen, J.; Bojkova, D.; Lage-Rupprecht, V.; Karki, R.; Lukassen, S.; Gadiya, Y.; Ravindra, N.G.; Das, S.; Baksi, S.; Domingo-Fernandez, D.; Lentzen, M.; Strivens, M.; Raschka, T.; Cinatl, J.; DeLong, L.N.; Gribbon, P.; Geisslinger, G.; Ciesek, S.; Dijk, D. van; Gardner, S.; Kodamullil, A.T.; Fröhlich, H.; Peitsch, M.; Jacobs, M.; Hoeng, J.; Eils, R.; Claussen, C.; Hofmann-Apitius, M.
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2021A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection
Ellinger, B.; Bojkova, D.; Zaliani, A.; Cinatl, J.; Claussen, C.; Westhaus, S.; Keminer, O.; Reinshagen, J.; Kuzikov, M.; Wolf, M.; Geisslinger, G.; Gribbon, P.; Ciesek, S.
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2020A high-throughput HIV-1 drug screening platform, based on lentiviral vectors and compatible with biosafety level-1
Ellinger, B.; Pohlmann, D.; Woens, J.; Jäkel, F.M.; Reinshagen, J.; Stocking, C.; Prassolov, V.S.; Fehse, B.; Riecken, K.
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2019Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
Moraes, C.B.; Witt, G.; Kuzikov, M.; Ellinper, B.; Calogeropoulou, T.; Prousis, K.C.; Mangani, S.; Pisa, F. di; Landi, G.; Dello Lacono, L.; Pozzi, C.; Freitas, L.H.; Pascoalino, B.D.; Bertolacini, C.P.; Behrens, B.; Keminer, O.; Leu, J.; Wolf, M.; Reinshagen, J.; Cordeiro-da-Silva, A.; Santarem, N.; Venturelli, A.; Wrigley, S.; Karunakaran, D.; Kebede, B.; Pohner, I.; Muller, W.; Panecka-Hofman, J.; Wade, R.C.; Fenske, M.; Clos, J.; Alunda, J.M.; Corral, M.J.; Uliassi, E.; Bolognesi, M.L.; Linciano, P.; Quotadamo, A.; Ferrari, S.; Santucci, M.; Borsari, C.; Costi, M.P.; Gul, S.
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2019Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
Ehrnhoefer, D.E.; Skotte, N.H.; Reinshagen, J.; Qiu, X.; Windshügel, B.; Jaishankar, P.; Ladha, S.; Petina, O.; Khankischpur, M.; Nguyen, Y.T.N.; Caron, N.S.; Razeto, A.; Meyer zu Rheda, M.; Deng, Y.; Huynh, K.T.; Wittig, I.; Gribbon, P.; Renslo, A.R.; Geffken, D.; Gul, S.; Hayden, M.R.
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2019Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics
Borsari, C.; Jiménez-Antón, M.D.; Eick, J.; Bifeld, E.; Torrado, J.J.; Olías-Molero, A.I.; Corral, M.J.; Santarem, N.; Baptista, C.; Severi, L.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Reinshagen, J.; Witt, G.; Linciano, P.; Tait, A.; Costantino, L.; Luciani, R.; Tejera Nevado, P.; Zander-Dinse, D.; Franco, C.H.; Ferrari, S.; Moraes, C.B.; Cordeiro-da-Silva, A.; Ponterini, G.; Clos, J.; Alunda, J.M.; Costi, M.P.
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2019SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti- Trypanosoma brucei Agent
Borsari, C.; Santarem, N.; Macedo, S.; Jiménez-Antón, M.D.; Torrado, J.J.; Olías-Molero, A.I.; Corral, M.J.; Tait, A.; Ferrari, S.; Costantino, L.; Luciani, R.; Ponterini, G.; Gul, S.; Kuzikov, M.; Ellinger, B.; Behrens, B.; Reinshagen, J.; Alunda, J.M.; Cordeiro-Da-Silva, A.; Costi, M.P.
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2017Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production
Kebede, B.; Wrigley, S.K.; Prashar, A.; Rahlff, J.; Wolf, M.; Reinshagen, J.; Gribbon, P.; Imhoff, J.F.; Silber, J.; Labes, A.; Ellinger, B.
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2017Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
Linciano, P.; Dawson, A.; Pöhner, I.; Costa, D.M.; Sá, M.S.; Cordeiro-da-Silva, A.; Luciani, R.; Gul, S.; Witt, G.; Ellinger, B.; Kuzikov, M.; Gribbon, P.; Reinshagen, J.; Wolf, M.; Behrens, B.; Hannaert, V.; Michels, P.A.M.; Nerini, E.; Pozzi, C.; Pisa, F. di; Landi, G.; Santarem, N.; Ferrari, S.; Saxena, P.; Lazzari, S.; Cannazza, G.; Freitas-Junior, L.H.; Moraes, C.B.; Pascoalino, B.S.; Alcântara, L.M.; Bertolacini, C.P.; Fontana, V.; Wittig, U.; Müller, W.; Wade, R.C.; Hunter, W.N.; Mangani, S.; Costantino, L.; Costi, M.P.
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2017A Label-Free Continuous Fluorescence-Based Assay for Monitoring Ornithine Decarboxylase Activity with a Synthetic Putrescine Receptor
Nilam, M.; Gribbon, P.; Reinshagen, J.; Cordts, K.; Schwedhelm, E.; Nau, W.M.; Hennig, A.
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2017Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
Borsari, C.; Santarem, N.; Torrado, J.; Olías, A.I.; Corral, M.J.; Baptista, C.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Witt, G.; Gribbon, P.; Reinshagen, J.; Linciano, P.; Tait, A.; Costantino, L.; Freitas-Junior, L.H.; Moraes, C.B.; Bruno dos Santos, P.; Alcântara, L.M.; Franco, C.H.; Bertolacini, C.D.; Fontana, V.; Tejera Nevado, P.; Clos, J.; Alunda, J.M.; Cordeiro-da-Silva, A.; Ferrari, S.; Costi, M.P.
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2017A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties
Zaini, M.A.; Müller, C.; Ackermann, T.; Reinshagen, J.; Kortman, G.; Pless, O.; Calkhoven, C.F.
Zeitschriftenaufsatz
2016Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs
Borsari, C.; Lucian, R.; Pozz, C.; Poehner, I.; Henrich, S.; Trande, M.; Cordeiro-Da-silva, A.; Santarem, N.; Baptista, C.; Tait, A.; Di Pisa, F.; Iacono, L.D.; Landi, G.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Reinshagen, J.; Witt, G.; Gribbon, P.; Kohler, M.; Keminer, O.; Behrens, B.; Costantino, L.; Nevado, P.T.; Bifeld, E.; Eick, J.; Clos, J.; Torrado, J.; Jiménez-Antón, M.D.; Corral, M.J.; Alunda, J.Ma.; Pellati, F.; Wade, R.C.; Ferrari, S.; Mangani, S.; Costi, M.P.
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